评分系统与生物标志物评估社区获得性肺炎严重程度的研究进展  

Research Progress of Scoring System and Biomarker Evaluation of Severity of Community-acquired Pneumonia

作　　者：郑佳熠 陶钰琦 解梓琛 孙克玉[1] ZHENG Jiayi;TAO Yuqi;XIE Zichen;SUN Keyu(Department of Emergency,Minhang Hospital Affiliated to Fudan University,Shanghai 201199,China)

机构地区：[1]复旦大学附属闵行医院急诊科,上海201199

出　　处：《医学综述》2024年第16期1999-2005,2012,共8页Medical Recapitulate

摘　　要：社区获得性肺炎(CAP)是全球范围内感染性疾病中发病率和死亡率较高的疾病。临床上依据医师的主观判断评估其严重程度存在不确定性,导致不必要的治疗及医疗过度。为解决这一问题,国内外各种CAP严重程度评分系统逐渐被开发出来,如CURB-65评分、简化版CURB-65评分、肺炎严重性指数评分。近年来也有部分生物标志物被用于预测CAP的严重程度,如中性粒细胞与淋巴细胞比值、单核细胞与淋巴细胞比值、血小板与淋巴细胞比值。但对于老年CAP患者,部分肺炎系统存在一定不足,后续可以基于现有的肺炎评分系统联合生物标志物对患者进行病情评估,从而提高评分系统的预测价值。Community-acquired pneumonia(CAP)is a highly prevalent and fatal infectious disease worldwide.In clinical practice,there is uncertainty in assessing the severity of CAP based on subjective judgment of physicians,leading to unnecessary treatment and medical overuse.To address this issue,various severity scoring systems for CAP have been gradually developed both domestically and internationally,such as CURB-65 scoring,simplified CURB-65 scoring and pneumonia severity index scoring.In recent years,some biomarkers have also been used to predict the severity of CAP,such as neutrophil-to-lymphocyte ratio,monocyte-to-lymphocyte ratio,and platelet-to-lymphocyte ratio.However,there are some limitations in existing pneumonia systems for elderly CAP patients.Subsequently,the existing pneumonia scoring system can be combined with biomarkers to evaluate the patient′s condition,thereby improving the predictive value of the scoring system.

关 键 词：社区获得性肺炎 疾病严重程度评分 生物标志物 

分 类 号：R563.1[医药卫生—呼吸系统]