肝脏胰岛素抵抗引起非酒精性脂肪性肝病相关机制研究进展  

Research progress on the mechanism of non-alcoholic fatty liver disease caused byhepatic insulin resistance

作　　者：张若男 何军华[1] ZHANG Ruonan;HE Junhua(Department of Endocrinology,The Second Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China)

机构地区：[1]山西医科大学第二医院内分泌科,山西太原030001

出　　处：《中国临床研究》2024年第7期998-1002,共5页Chinese Journal of Clinical Research

基　　金：山西省科技合作交流专项项目(202204041101024);山西省回国留学人员科研资助项目(2021-169)。

摘　　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)指除外酒精和其他明确损肝因素所致的肝细胞弥漫性大泡性脂肪变性和脂肪贮积为特征的临床病理综合征。在病因学上,NAFLD与肝脏胰岛素抵抗(insulin resistance,IR)具有高度的相关性,阐明肝脏IR发病机制有望为NAFLD药物研究提供理论支持。因此,本文就肝脏IR引起NAFLD相关机制的研究进展做一综述。Non-alcoholic fatty liver disease(NAFLD)refers to a clinicopathological syndrome characterized by macrovesicular steatosis and lipid accumulation of hepatocytes,except for alcohol and other specific factors associated with liver damage.In terms of etiology,NAFLD is highly correlated with hepatic insulin resistance(IR).Elucidation of the pathogenesis of hepatic IR is expected to provide theoretical support for drug research in NAFLD.Therefore,this article reviews the research progress on the mechanism of NAFLD caused by hepatic IR.

关 键 词：非酒精性脂肪性肝病 肝脏胰岛素抵抗 分子机制 脂质代谢 炎症反应 

分 类 号：R587.2[医药卫生—内分泌] R575.5[医药卫生—内科学]