A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages  

作　　者：Lan-Lan Li Yu Zhao Li-Jia Pan Jian-Bin Xu Yi Shi 

机构地区：[1]College of Mechanical and Electrical Engineering,Henan Agricultural University,Zhengzhou 450002,China [2]School of Electronic Science and Engineering,Collaborative Innovation Center of Advanced Microstructures,Nanjing University,Nanjing210093,China [3]Department of Electronic Engineering,The Chinese University of HongKong,Hongkong 999077,China

出　　处：《Rare Metals》2024年第5期2184-2192,共9页稀有金属（英文版）

基　　金：financially supported by National Key Research and Development Program of China(No.2021YFA1401103);the National Natural Science Foundation of China(Nos.61825403,61921005 and 61904049)。

摘　　要：Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is critical.This study developed a direct electrochemical biosensor for glucose based on nitrogen-doped carbon nanocages(NCNCs).NCNCs possess a large specific surface area of 1395 m^(2)·g^(-1),a high N atomic content of 9.37%and good biocompatibility,which is favorable for enzyme loading and electron transfer.The surface average concentration of electroactive glucose oxidase on NCNCs was 2.82×10^(-10)mol·cm^(-2).The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7μA·(mmol·L^(-1))^(-1)·cm^(-2),rapid response time of 5 s and an impressive electron-transferrate constant(ks)of 1.87 s^(-1).Furthermore,we investigated an NCNC-based direct electron transfer(DET)biosensor for sweat glucose detection,which demonstrated tremendous promise for non-invasive wearable diabetes diagnosis.

关 键 词：Direct electron transfer(DET) Nitrogen-doped carbon nanocages(NCNCs) Glucose oxidase BIOSENSOR 

分 类 号：Q503[生物学—生物化学] O657.1[理学—分析化学] TP212.3[理学—化学]