中医外治法治疗颈源性高血压的系统评价  

Systematic Evaluation of External Treatment of Traditional Chinese Medicine for Cervical Hypertension

作　　者：马勇博 滑振 王靖涵 张磊[2] MA Yongbo;HUA Zhen;WANG Jinghan;ZHANG Lei(Shandong University of Traditional Chinese Medicine,Jinan 250011,Shandong,China)

机构地区：[1]山东中医药大学,济南250011 [2]山东中医药大学附属医院,济南250011

出　　处：《中西医结合心脑血管病杂志》2024年第14期2505-2513,共9页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金面上项目(No.81974561);山东省中医药科技发展计划项目(No.2019-0190,2017-048,2017-055);山东省自然科学基金项目(No.ZR2017BH091,ZR2019BH033,ZR2021MH410);2017年中国博士后科学基金项目(No.2017M612342);2017年山东省保健科技协会科学技术课题项目(No.SDBJKT20170080);齐鲁卫生与健康杰出青年人才项目;中西医结合心血管泰山学者工程专项经费资助项目;2022年齐鲁医派中医学术流派传承项目。

摘　　要：目的:系统评价中医外治法治疗颈源性高血压的临床疗效。方法:检索中国知网(CNKI)、重庆维普(VIP)、万方数据库、PubMed、EMbase、the Cochrane Library数据库中有关中医外治法治疗颈源性高血压的随机对照试验,检索时限从建库至2022年11月10日。由两名研究员独立筛选文献、提取资料并进行偏倚风险分析;对纳入的文献采用RevMan 5.4软件进行Meta分析。结果:共纳入20篇文献,涉及1466例病人,其中观察组734例,对照组732例。Meta分析结果显示,与对照组比较,观察组收缩压[MD=-11.03,95%CI(-14.42,-7.63),P<0.00001]、舒张压[MD=-7.42,95%CI(-8.80,-6.03),P<0.00001]、颈椎功能障碍指数(NDI)评分[MD=-6.26,95%CI(-10.81,-1.72),P=0.007]、疼痛视觉模拟量表(VAS)评分[MD=-2.60,95%CI(-3.48,-1.73),P<0.00001]降低,降压疗效[MD=1.24,95%CI(1.11,1.39),P=0.0001]提高,中医症状[MD=-3.75,95%CI(-5.33,-2.16),P<0.00001]改善,差异均有统计学意义。结论:现有证据表明,中医外治法治疗颈源性高血压是安全有效的,可改善病人血压和相关临床症状,受限于研究质量与数量,仍需大样本、高质量的研究进一步评价验证。Objective:To systematically evaluate the clinical effect of external treatment of traditional Chinese medicine for cervical hypertension.Methods:Randomized controlled trials of external treatment for cervical hypertension from the database establishment to November 10,2022 were searched from CNKI,VIP,WanFang Database,PubMed,EMbase and the Cochrane Library.Two researchers independently screened the literatures,extracted data,and conducted bias risk analysis.RevMan 5.4 software were used for Meta-analysis.Results:A total of 20 literatures were included,including 1466 patients,with 734 patients in the observation group and 732 patients in the control group.The results of Meta-analysis showed that compared with the control group,systolic blood pressure(MD=-11.03,95%CI-14.42--7.63,P<0.00001),diastolic blood pressure(MD=-7.42,95%CI-8.80--6.03,P<0.00001),Neck Disability Index(NDI)score(MD=-6.26,95%CI-10.81--1.72,P=0.007),Visual Analogue Scale(VAS)score(MD=-2.60,95%CI-3.48--1.73,P<0.00001)in the observation group decreased,antihypertensive efficacy(MD=1.24,95%CI 1.11-1.39,P=0.0001)increased,traditional Chinese medicine symptoms(MD=-3.75,95%CI-5.33--2.16,P<0.00001)improved,all differences were statistically significant.Conclusion:The current evidence showed that external treatment of traditional Chinese medicine for cervical hypertension was safe and effective,and it could improve patients′blood pressure and related clinical symptoms.However,there were some poor the quality and quantity of literatures,further evaluation and large samples and high-quality studies were still needed.

关 键 词：颈源性高血压 中医外治法 随机对照试验 系统评价 循证医学 

分 类 号：R259[医药卫生—中西医结合]