母-胎界面滋养细胞自噬诱发胎盘植入的研究进展  

Research progress of placental implantation induced by trophoblast autophagy at the maternal-fetal interface

作　　者：谭海霞 王彩虹 薛莲 杨少良[2] 任柏萱 杨晓棠 TAN Haixia;WANG Caihong;XUE Lian;YANG Shaoliang;REN Baixuan;YANG Xiaotang(Department of Obstetrics and Gynecology,Zhangye People’s Hospital Affiliated to Hexi University,Gansu Province,Zhangye 734000,China;Fudan University Affiliated Obstetr ics and Gynecology Hospital,Shanghai 200000,China)

机构地区：[1]河西学院附属张掖人民医院妇产科,甘肃张掖734000 [2]复旦大学附属妇产科医院,上海200000

出　　处：《妇儿健康导刊》2024年第13期25-29,共5页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：甘肃省高等学校创新基金项目(2022B-193);河西学院校长基金创新团队项目(CXTD2023007)。

摘　　要：自噬是一种维持真核细胞体内稳态的催化过程,主要将受损大分子和细胞质成分降解,为细胞合成提供新的构建物质。越来越多的研究表明,自噬在平衡免疫和炎症方面发挥关键作用,特别是源自胚胎的绒毛外滋养细胞,在与胚胎母体接触的过程中与其他细胞进行交互对话,影响胚胎的发生、植入和妊娠维持。在母-胎界面中,自噬表达与滋养细胞的存活、侵袭以及抗病毒等生物学功能密切相关,异常表达将导致一系列病理状态,其中滋养细胞作为胎盘的主要成分,过度侵袭是发生胎盘植入的主要因素。本文对近年来母-胎界面滋养细胞自噬诱发胎盘植入的研究进行综述。Autophagy is a catalytic process that maintains the homeostasis of eukaryotic cells.It mainly degrades damaged macromolecules and cytoplasmic components to provide new building materials for cell synthesis.More and more studies have shown that autophagy plays a key role in balancing immunity and inflammation.In particular,the extravillous trophoblast cells derived from embryo conduct interactive dialogue with other cells during the process of contact with the mother embryo,affecting the occurrence,implantation of embryo,and pregnancy maintenance.In the maternal-fetal interface,the expression of autophagy is closely related to the survival,invasion,and antiviral function of trophoblast,and abnormal expression will lead to a series of pathological states.Trophoblast is the main component of the placenta,and excessive invasion is the main factor for placental implantation.This article reviews recent studies on trophoblast autophagy inducing placental implantation at the maternal-fetal interface.

关 键 词：滋养细胞 自噬 胎盘植入 母-胎界面 

分 类 号：R714.2[医药卫生—妇产科学]