犬小孢子菌治疗方法的研究进展  

Research Progress on the Treatment Method of Microsporum canis

作　　者：刘潼 韩谨泽 任天宇 张加力[1] LIU Tong;HAN Jinze;REN Tianyu;ZHANG Jiali(College of Animal Medicine,Jilin Agricultural University,Changchun 130118,China)

机构地区：[1]吉林农业大学动物医学院,长春130118

出　　处：《经济动物学报》2024年第2期152-156,共5页Journal of Economic Animal

基　　金：吉林省科技攻关计划项目(20190301009NY)。

摘　　要：犬小孢子菌是犬和猫皮肤真菌病的主要致病菌,在临床治疗中通常采用化学药物,但由于化学药物的长期使用,病菌已产生耐药性。目前,应用植物源性提取物治疗犬小孢子菌引起的皮肤病成为研究热点。枯草芽孢杆菌产生的环脂肽(CLPs)能与犬小孢子菌产生拮抗作用,抑制或杀灭菌体,进而达到治疗的目的;亚甲基蓝介导的抗菌光动力疗法(MB-APDT)对犬小孢子菌病也有良好的治疗效果。对上述犬小孢子菌病的治疗方法进行综述,以期为该病的临床治疗提供参考。Microsporum canis is the main causative agent of dermatomycosis in dogs and cats,and chemical drugs are usually used in clinical treatment,but due to the long-term use of chemical drugs,the pathogens have developed drug resistance.Currently,the application of plant-derived extracts for the treatment of skin diseases caused by canine microsporidia has become a research hotspot.The cyclic lipopeptides(CLPs) produced by Bacillus subtilis can antagonize with Microsporum canis,inhibit or kill the bacterium to achieve the therapeutic purpose.Methylene bluemediated antimicrobial photodynamic therapy(MB-APDT) also has good therapeutic effect on Microsporum canis.The above therapeutic methods for Microsporum canis are reviewed with a view to providing reference for the clinical treatment of this disease.

关 键 词：犬小孢子菌 抗真菌药 植物提取物 枯草芽孢杆菌CLPs MB-APDT 

分 类 号：S829.2[农业科学—畜牧学]