pH敏感脂质体在肿瘤治疗领域的研究进展  

Advances in pH I-sensitive liposomes for cancer therapy

作　　者：昌天鹤 全姬善[2] CHANG Tianhe;QUAN Jishan(College of Integration Science,Yanbian University,Yanji 133002,CHN;College of Pharmacy,Yanbian University,Yanji 133002,CHN)

机构地区：[1]延边大学融合学院,吉林延吉133002 [2]延边大学药学院,吉林延吉133002

出　　处：《河南大学学报（医学版）》2024年第3期157-161,共5页Journal of Henan University:Medical Science

摘　　要：pH敏感脂质体作为药物或核酸的载体可以在肿瘤部位选择性释放药物,减少抗肿瘤药物或核酸在血液循环过程中的释放,降低对正常组织的毒副作用,提高药物/核酸的生物利用度。本文对近五年来用于治疗肿瘤的pH敏感脂质体的研究进行了综述,介绍了pH敏感脂质体的制备方法、响应机制和应用,为pH敏感脂质体在抗肿瘤药物载体设计方面的研究提供参考。As one of drug or gene carriers,pH-sensitive liposome can selectively release drugs at tumor tissues,reduce the drug leakage during the blood circulation,reduce side effects of drugs.leading to enhanced drug bioavailability.The references on pH-sensitive liposomes in five years are summarized to use for cancer therapy,and introduce the preparation methods,response mechanism and application of pH-sensitive liposomes,and provide references for the research of pH-sensitive liposomes in the design of anti-tumor drug carriers.

关 键 词：pH敏感脂质体 药物载体 肿瘤治疗 

分 类 号：R944[医药卫生—药剂学]