方氏头针结合子午流注纳子法对失眠患者血清GABA、Glu及睡眠质量的影响  

Effect of Fang's Scalp Acupuncture Combined with Nazi Method of Midnight-Noon Ebb-Flow on Serum GABA and Glu and Sleep Quality in Patients with Insomnia

作　　者：刘媛媛 安琪 安军明 刘艳芳 马凯靖 赵镇涛 LIU Yuanyuan;AN Qi;AN Junming;LIU Yanfang;MA Kaijing;ZHAO Zhentao(Shaanxi University of Chinese Medicine,Xianyang 712000,China;Beijing University of Chinese Medicine,Beijing 100029,China;Xi’an Hospital of Traditional Chinese Medicine,Xi’an 710021,China)

机构地区：[1]陕西中医药大学,陕西咸阳712000 [2]北京中医药大学,北京100029 [3]西安市中医医院,陕西西安710021

出　　处：《针灸临床杂志》2024年第6期43-47,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：陕西省科技厅社会发展领域项目,编号:2021SF-282;陕西省中医药管理局重点科研项目,编号:2021-01-22-007;陕西省中医药管理局方氏头针重点研究室项目,编号:陕中医药发[2018]32号;陕西省中医药管理局长安方氏头针流派传承工作室项目,编号:陕中医药发[2018]40号;西安市地方级领军人才项目,编号:XARC210159。

摘　　要：目的:探索方氏头针结合子午流注纳子法治疗失眠症的疗效,并探讨其可能的机制。方法:选择60例失眠症患者随机分为观察组(30例)和对照组(30例,脱落1例)。对照组给予常规针刺,观察组给予方氏头针结合子午流注纳子法针刺治疗。两组患者1次/d,每周5次,连续2周。分别于治疗前后评定匹兹堡睡眠质量指数量表(PSQI)评分、血清γ-氨基丁酸(GABA)及谷氨酸(Glu)的变化情况。结果:治疗2周,两组患者PSQI均较治疗前下降,差异有统计学意义(P<0.05)。治疗后血清GABA水平较治疗前比较均有所上升,Glu水平较治疗前比较均有所下降。方氏头针联合子午流注纳子法组在血清GABA水平上与常规针刺组比较,差异具有统计学意义(P<0.05)。结论:方氏头针结合子午流注纳子法治疗失眠确有疗效,能够明显地改善患者的临床症状,其机制可能与调节血清GABA、Glu水平有关。Objective:To explore the therapeutic efficacy of Fang's scalp acupuncture combined with Nazi method of midnight-noon ebb-flow in treatment of insomnia,and to explore its possible mechanisms.Methods:60 patients with insomnia were randomly divided into the observation group(n=30) and the control group(n=30,one case dropping out).The control group was treated with conventional acupuncture,whereas the observation group was treated with Fang's scalp acupuncture combined with Nazi method of midnight-noon ebb-flow.Both groups were needled once a day,5 times a week for 2 weeks.The score of Pittsburgh Sleep Quality Index(PSQI),and the serum levels of γ-aminobutyric acid(GABA) and glutamate(Glu) were assessed before and after the treatment in the two groups.Results:After 2 weeks of treatment,the score of PSQI was significantly decreased in both groups compared to that before the treatment in the two groups;the serum level of GABA was increased and the serum level of Glu was decreased compared to that before the treatment in the two groups.There was a statistical difference in the serum level of GABA between the two groups after the treatment(P<0.05).Conclusion:Fang's scalp acupuncture combined with Nazi method of midnight-noon ebb-flow is indeed efficacious in treatment of insomnia,it can significantly improve the clinical symptoms,and its mechanism may be related to the regulation of serum levels of GABA and Glu.

关 键 词：失眠 方氏头针 子午流注纳子法 Γ-氨基丁酸 谷氨酸 随机对照试验 

分 类 号：R246.6[医药卫生—针灸推拿学]