妊娠期低剂量抗生素暴露对新生儿肠道菌群及健康影响的研究进展  

Progress in the impact of low-dose antibiotic exposure during pregnancy on neonatal gut microbiota

作　　者：刘英 李雅清 马良坤[2] Liu Ying;Li Yaqing;Ma Liangkun(Scientific Research Laboratory,Datong First People's Hospital(Women and Children Hospital,Shanxi Datong University),Datong 037009,China;Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]大同市第一人民医院(山西大同大学附属妇女儿童医院)科研实验室,大同037009 [2]中国医学科学院北京协和医学院北京协和医院妇产科,北京100730

出　　处：《中华围产医学杂志》2024年第7期599-602,共4页Chinese Journal of Perinatal Medicine

基　　金：山西省卫生健康委项目(2022124)。

摘　　要：残留在孕妇体内的动物源性低剂量抗生素检出率较高。低剂量抗生素累积效应将影响新生儿肠道菌群的建立,导致微生物菌群结构的失衡。低剂量抗生素的暴露可能对孕妇、胎儿和新生儿健康均产生不利的影响。本文综述了妊娠期持续低剂量抗生素暴露对新生儿肠道菌群的建立与定植的影响,新生儿肠道菌群多样性的改变及新生儿生长发育不良的影响研究进展。The detection rate of animal-derived low-dose antibiotics that reside in pregnant women's bodies is relatively high,and the cumulative effect impacts the establishment of the neonatal gut microbiota,leading to an imbalance in the microbial community structure.Exposure to low-dose antibiotics may have adverse effects on the health of pregnant women,fetuses,and newborns.This article reviews the impact of continuous low-dose antibiotic exposure during pregnancy on the establishment and colonization of neonatal gut microbiota,the alteration of the diversity of the neonatal gut microbiota,and the adverse effects on long-term growth and development.

关 键 词：妊娠 低剂量抗生素 新生儿 肠道菌群 

分 类 号：R714[医药卫生—妇产科学]