基于ComBat方法调谐^(18)F-FDG PET脑显像的初步研究  

Harmonization of ^(18)F-FDG PET brain imaging based on ComBat method:a pilot study

作　　者：焦方阳 王丹 朱毓华 鲁佳荧 琚紫昭 徐蒨 葛璟洁[1] 华涛[1] 吴平[1] 施匡宇 管一晖[1] 左传涛[1] Jiao Fangyang;Wang Dan;Zhu Yuhua;Lu Jiaying;Ju Zizhao;Xu Qian;Ge Jingjie;Hua Tao;Wu Ping;Shi Kuangyu;Guan Yihui;Zuo Chuantao(Department of Nuclear Medicine&PET Center,Huashan Hospital,Fudan University,Shanghai 200235,China;Department of Nuclear Medicine,Daping Hospital,Army Medical University,Chongqing 400042,China;Department of Nuclear Medicine,University of Bern,Bern 3010,Switzerland)

机构地区：[1]复旦大学附属华山医院核医学/PET中心,上海200235 [2]陆军军医大学大坪医院核医学科,重庆400042 [3]瑞士伯尔尼大学核医学科,伯尔尼3010

出　　处：《中华核医学与分子影像杂志》2024年第7期412-416,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金(81971641,82021002):上海市科学技术委员会"科技创新行动计划"医学创新研究专项(21Y11903300)。

摘　　要：目的基于ComBat方法对同一厂家不同型号PET采集的脑显像数据进行影像调谐,探讨该同质化方法对数据中心效应的影响。方法用2台不同型号PET/CT仪(德国Siemens Biograph64 TruePoint与Biograph128 mCT)对三维(3D)Hoffman脑模型进行^(18)F-FDG PET显像;对14名健康受试者[男8名、女6名;年龄(57.7±9.5)岁]用Biograph64 TruePoint、12名健康受试者[男9名、女3名;年龄(55.8±10.5)岁]用Biograph128 mCT PET/CT仪行^(18)F-FDG PET脑显像(受试者来源:复旦大学附属华山医院;时间:2020年11月至2023年3月)。依据自动解剖标记(AAL)脑模板将全脑划分为116个脑区,应用ComBat同质化方法对采集的脑模型及健康受试者ROI内PET数据进行影像调谐。对2台PET/CT所得数据影像调谐前后的放射性计数、SUV比值(SUVR)进行Mann-Whitney U检验;对健康受试者的数据进行基于体素的统计参数图(SPM)两独立样本t检验。结果对于3D Hoffman脑模型,Biograph64 TruePoint和Biograph128 mCT PET/CT的调谐前放射性计数[5590.33(4961.67,6102.95)与6116.03(5420.97,6660.66);z=-9.35,P<0.001]、SUVR[1.35(1.19,1.47)与1.37(1.21,1.49);z=-3.63,P<0.001]差异均具有统计学意义,而在调谐后指标差异没有统计学意义[放射性计数:5845.95(5192.68,6378.63)与5859.17(5193.84,6380.52),SUVR:1.35(1.20,1.48)与1.36(1.20,1.49);均z=-0.68,均P=0.498]。在健康受试者中,调谐前19个脑区的放射性计数[12422.78(11181.60,13424.28)~18166.40(15882.80,18666.27);z值:-3.24~-2.06,均P<0.05]、40个脑区的SUVR[1.46(1.41,1.52)~2.28(2.16,2.36);z值:-3.65~-1.70,均P<0.05]在2台仪器间差异有统计学意义;调谐后全部116个脑区差异无统计学意义[放射性计数:9243.55(8502.38,9854.87)~20419.60(19931.51,21179.43);z值:-0.72~0,均P>0.05;SUVR:1.04(1.01,1.09)~2.32(2.24,2.40);z值:-0.82~0,均P>0.05]。SPM分析显示调谐前2台PET/CT仪采集的健康受试者脑内葡萄糖代谢在大脑皮质、基底节、中脑及小脑存在差异,调谐后有差异的脑区明显�Objective To perform harmonization based on the ComBat method for PET brain imaging scanned by different types of scanners from the same manufacturer and explored its effect on center effect.Methods The three-dimensional(3D)Hoffman brain model was scanned by two different PET/CT instruments(Siemens Biograph64 TruePoint and Biograph128 mCT).Fourteen healthy subjects(8 males,6 females,age:(57.7±9.5)years)underwent ^(18)F-FDG PET/CT on Siemens Biograph64 TruePoint and 12 healthy subjects(9 males,3 females,age:(55.8±10.5)years)underwent ^(18)F-FDG PET/CT on Siemens Biograph128 mCT(all from Huashan Hospital,Fudan University;from November 2020 to March 2023).The whole brain was divided into 116 brain regions based on the anatomical automatic labeling(AAL)brain template.The ComBat method was applied to harmonized the PET data from brain model and healthy subjects.Mann-Whitney U test was performed on the radioactive counts and SUV ratios(SUVR)before and after homogenization acquired by both PET/CT instruments.Voxel-based statistical parametric mapping(SPM)independent-sample t test was also performed on data of healthy subjects.Results In 3D Hoffman brain model,radioactivity counts(5590.33(4961.67,6102.95)vs 6116.03(5420.97,6660.66);z=-9.35,P<0.001)and SUVR(1.35(1.19,1.47)vs 1.37(1.21,1.49);z=-3.63,P<0.001)were significantly different between the two PET/CT scanners before harmonization and not after harmonization(radioactivity counts:5845.95(5192.68,6378.63)vs 5859.17(5193.84,6380.52);SUVR:1.35(1.20,1.48)vs 1.36(1.20,1.49);both z=-0.68,both P=0.498).In the healthy subjects,radioactive counts in 19 brain regions(12422.78(11181.60,13424.28)-18166.40(15882.80,18666.27);z values:from-3.24 to-2.06,all P<0.05)and SUVR in 40 brain regions(1.46(1.41,1.52)-2.28(2.16,2.36);z values:from-3.65 to-1.70,all P<0.05)were significantly different between the two scanners before harmonization,while after homogenization there were no statistical differences for all 116 brain regions(radioactivity counts:9243.55(8502.38,9854.87)-20419.60(1

关 键 词：脑 图像处理 计算机辅助 正电子发射断层显像术 氟脱氧葡萄糖F18 

分 类 号：R817[医药卫生—影像医学与核医学]