新型冠状病毒感染病例临床特征及中药治疗疗效分析  

Clinical characteristics of novel coronavirus infection cases and analysis of therapeutic effect of traditional

作　　者：钱秋红[1] 吕红[1] 舒君[1] 陶政正[1] 沈陆鸿 QIAN Qiuhong;LV Hong;SHU Jun;TAO Zhengzheng;SHEN Luhong(Traditional Chinese Medicine Hospital of Taicang City,Suzhou City,Suzhou City,Taicang 215400,Jiangsu,China)

机构地区：[1]江苏省苏州市太仓市中医医院,江苏太仓215400

出　　处：《中国病原生物学杂志》2024年第8期941-945,共5页Journal of Pathogen Biology

基　　金：国家中医药管理局名医验方评价与转化重点研究室项目(No.FM-P8-2019081401);太仓市科技局项目(No.TC2014SW02,TC2016SFYL14,TC2019JCYL11)。

摘　　要：目的 探析本地区新型冠状病毒感染病例的临床特征及中药干预疗效。方法 选取本院肺病科收治的265例新型冠状病毒感染确诊病例为本次研究对象。通过院内电子病例系统,收集患者基础资料、既往病史、临床症状,对患者进行临床分型。由我院两名具有中医临床经验或经专业培训的中医师对患者舌象进行判断及辩病辩证。对所有患者采用荧光定量PCR法进行核酸检测,根据新型冠状病毒基因测序结果进行分组。对比感染不同毒株、不同性别病例的临床特征。对轻型新型冠状病毒感染病例给予中药处方治疗,分析服用中药后核酸阳性天数与服用中药前核酸阳性天数的相关性。结果 265例新型冠状病毒感染病例中,轻型感染者102例,普通型感染者93例,重型感染者54例,危重型感染者16例。26例未接种疫苗,15例接种一针疫苗,132例接种两针疫苗,92例接种三针疫苗。80例合并高血压,45例合并糖尿病,40例合并冠状动脉粥样硬化性心脏病,21例慢性阻塞性肺疾病。265例感染病例中,德尔塔变异株感染67例,奥密克戎变异株感染198例。不同毒株感染病例分组发热、咽痛、胸闷比例差异有统计学意义(P<0.05),性别、咳嗽/咳痰、鼻塞、腹泻、乏力、肌肉酸痛、恶心呕吐、嗅觉/味觉减退比例差异无统计学意义(P>0.05)。不同性别分组病例发热、咳嗽/咳痰、咽痛、鼻塞、腹泻、乏力、肌肉酸痛、恶心呕吐、嗅觉/味觉减退比例差异无统计学意义(P>0.05),胸闷比例差异有统计学意义(P<0.05)。265例病例舌质主要为淡红舌(33.96%)与红舌(19.25%),舌苔主要为黄白腻苔(35.09%)与薄黄腻苔(24.91%)。130例患者辨证分型为基础型,82例为湿热型,29例为寒湿型,18例为肝郁型,4例为风热型,2例为阴虚型。62例轻型感染病例于核酸检测阳性当日给予中药治疗,服用中药治疗后核酸阳性天数为(3.52±1.00)d。40例轻型感Objective To explore the clinical characteristics of novel coronavirus infection cases in this region and the efficacy of traditional Chinese medicine intervention. Methods 265 confirmed cases of novel coronavirus infection admitted to the pulmonary disease department of our hospital were selected as the subjects of this study.The patient basic information, medical history, and clinical symptoms were collected by the hospital's electronic case system to classify patients clinically.Two Chinese medicine practitioners with clinical experience or professional training in traditional Chinese medicine from our hospital will assess the patient's tongue condition and differentiate the disease. All patients were detected by fluorescence quantitative PCR,and were divided into groups according to the results of novel coronavirus gene sequencing. The clinical characteristics of cases infected with different strains and genders were compared. The mild novel coronavirus infection cases were treated with Chinese medicine prescriptions, and the correlation between the nucleic acid positive days after taking Chinese medicine and the nucleic acid positive days before taking Chinese medicine was analyzed. Results Among 265 cases of novel coronavirus infection, 102 cases were mild, 93 cases were common, 54 cases were severe, and 16 cases were critical. 26 cases were not vaccinated, 15 cases received one dose of vaccine, 132 cases received two doses of vaccine, and 92 cases received three doses of vaccine. 80 cases were complicated with hypertension, 45 cases with diabetes, 40 cases with coronary atherosclerotic heart disease, and 21 cases with chronic obstructive pulmonary disease. Among the 265 cases of infection, there were 67 cases of Delta variant infection and 198 cases of Omicron variant infection. There was a statistically significant difference(P<0.05) in the proportion of fever, sore throat, and chest tightness among different strains of infection cases. However, there was no statistically significant difference(P>0.05) in

关 键 词：新型冠状病毒感染 临床特征 中药疗效 

分 类 号：R259[医药卫生—中西医结合]