类风湿性关节炎病情与牙周病原菌感染的关系研究进展  

Research progress on the relationship between the progression of rheumatoid arthritis and periodontal pathogen infection

作　　者：邹国强 刘英[2] 王旭凤 邹欣甫 刘乾 王悦 孟祥雨 ZOU Guoqiang;LIU Ying;WANG Xufeng;ZOU Xinfu;LIU Qian;WANG Yue;MENG Xiangyu(The First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Jinan 250000,China;Department of Rheumatology and Immunology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine)

机构地区：[1]山东中医药大学第一临床医学院,山东济南250000 [2]山东中医药大学附属医院风湿免疫科

出　　处：《中国病原生物学杂志》2024年第8期990-992,F0003,共4页Journal of Pathogen Biology

基　　金：山东省自然科学基金面上项目(No.ZR2023MH332)。

摘　　要：类风湿性关节炎(RA)和牙周病是两种常见的慢性疾病,近年来研究发现二者间存在密切关联。牙周病原菌感染可能影响RA的病情进展,通过产生酶类、毒素等机制加剧关节炎症状。深入了解这一关系不仅有助于更全面地认识RA的发病机制,还为临床治疗与预防提供了新的思路。通过控制牙周病原菌感染,可能为RA患者提供新的治疗策略,减轻关节炎症状,提高生活质量。本文对RA与牙周病原菌感染的流行病学特征、共同病理机制以及相互影响进行综述,旨在为临床预防该病提供参考。Rheumatoid arthritis(RA) and periodontal disease are two common chronic diseases. Recent studies have found a close relationship between them. Periodontal pathogen infection may affect the progression of RA and aggravate the symptoms of arthritis through the production of enzymes and toxins. In-depth understanding of this relationship not only contributes to a more comprehensive understanding of the pathogenesis of RA,but also provides a new idea for clinical treatment and prevention. By controlling periodontal pathogenic bacterial infection, RA patients may be provided with new treatment strategies to reduce arthritis symptoms and improve quality of life. In this paper, the epidemiological characteristics, common pathological mechanism and mutual influence of RA and periodontal pathogenic bacteria infection were reviewed, aiming to provide reference for clinical prevention of this disease.

关 键 词：类风湿性关节炎 病情进展 牙周病原菌 感染 综述 

分 类 号：R593.22[医药卫生—内科学] R781.4[医药卫生—临床医学]