寿胎丸加减治疗复发性流产的疗效及对患者凝血功能、Th17细胞相关因子的影响  

Effect of Modified Shoutai Pill on Recurrent Miscarriage and Its Influence on Coagulation Function and Th17 Cell Related Factors

作　　者：张燕[1] 邵岚[1] 范红芳 吕克蔺[1] 赵青 蒋蕾 ZHANG Yan;SHAO Lan;FAN Hongfang;LV Kelin;ZHAO Qing;JIANG Lei(The Sixth Hospital of Shijiazhuang City,Shijiazhuang 050000,China;The Fourth Hospital of Shijiazhuang City,Shijiazhuang 050031,China)

机构地区：[1]石家庄市第六医院,河北石家庄050000 [2]石家庄市第四医院,河北石家庄050031

出　　处：《中医药学报》2024年第8期61-66,共6页Acta Chinese Medicine and Pharmacology

基　　金：河北省自然科学基金项目(H2021206396)。

摘　　要：目的:探究寿胎丸加减治疗复发性流产的疗效及其对患者凝血功能、辅助T淋巴细胞17(Th17)细胞相关因子的影响。方法:对2021年3月—2022年3月石家庄市第六医院收治的120例复发性流产患者相关资料予以回顾性分析,按治疗方式将患者分为对照组与研究组,对照组57例接受黄体酮治疗,研究组63例在对照组基础上加用寿胎丸加减治疗。比较两组临床疗效,治疗前后中医证候积分、凝血功能、Th17与调节性T细胞(Treg)水平、Th17/Treg细胞相关因子,以及不良反应发生率。结果:研究组患者临床总有效率90.48%高于对照组75.44%(P<0.05);两组患者治疗后中医证候积分、凝血功能、Th17与Treg水平、Th17/Treg细胞相关因子均明显改善(P<0.01),研究组患者治疗后中医证候积分均明显低于对照组(P<0.01),研究组患者治疗后中医证候积分、凝血功能、Th17与Treg水平、Th17/Treg细胞相关因子等改善均优于对照组(P<0.01);研究组患者治疗期间不良反应发生率7.94%低于对照组12.28%,但差异无统计学意义(P>0.05)。结论:应用寿胎丸加减治疗复发性流产疗效显著,有助于减轻患者凝血功能障碍,纠正患者Th17细胞相关因子水平异常,临床应用效果良好。Objective:To explore the efficacy of modified Shoutai pill in the treatment of recurrent miscarriage and its effects on patients coagulation function and levels of T helper 17(Th17)cell-related factors.Methods:A retrospective analysis was conducted on 120 cases of recurrent miscarriage treated in our hospital from March 2021 to March 2022.Patients were divided into a control group and a study group according to the treatment method.The control group(n=57)received progesterone treatment,while the study group(n=63)received modified Shoutai pill in addition to progesterone.The therapeutic efficacy,TCM syndrome scores,coagulation function,levels of Th17 cells and regulatory T cells(Treg),Th17/Treg cell-related factors,and adverse reaction rates were compared between the two groups.Results:The total effective rate in the study group(90.48%)was higher than that in the control group(75.44%)(P<0.05).After treatment,the TCM syndrome scores,coagulation function,levels of Th17 cells and Treg,Th17/Treg cell-related factors were significantly improved in both groups(P<0.05).The TCM syndrome scores after treatment in the study group were significantly lower than those in the control group(P<0.05),and the improvements in TCM syndrome scores,coagulation function,levels of Th17 cells and Treg,Th17/Treg cell-related factors were higher in the study group than in the control group(P<0.05).The incidence of adverse reactions during treatment was lower in the study group(7.94%)than in the control group(12.28%),but the difference was not statistically significant(P>0.05).Conclusion:Modified Shoutai pill combined with progesterone treatment for recurrent miscarriage show excellent efficacy,help alleviate patients coagulation dysfunction,correct abnormal levels of Th17 cell-related factors,and demonstrate outstanding clinical application effects.

关 键 词：寿胎丸加减 复发性流产 凝血功能 Th17细胞相关因子 

分 类 号：R271.4[医药卫生—中医妇科学]