清毒百炎消外敷对急慢性创面愈合的应用效果  

Study on the application of topical application of Qingdu Baiyanxiao on the healing of acute and chronic wounds

作　　者：俞霆钧 陈文杰 周燕玉 YU Tingjun;CHEN Wenjie;ZHOU Yanyu(Emergency Trauma Centre,Jiujiang NO.1 People's Hospital,Jiujiang 332000,Jiangxi,China;Department of Orthopaedics,Jiujiang NO.1 People's Hospital,Jiujiang 332000,Jiangxi,China)

机构地区：[1]江西省九江市第一人民医院急诊创伤中心,江西九江332000 [2]江西省九江市第一人民医院骨科,江西九江332000

出　　处：《右江医学》2024年第6期514-517,共4页Chinese Youjiang Medical Journal

基　　金：江西省中医药管理局科技计划项目(2023B0485)。

摘　　要：目的研究清毒百炎消外敷在急慢性创面愈合中的应用效果。方法按随机数字表将2021年7月—2023年7月于江西省九江市第一人民医院治疗的84例急慢性创面患者分为两组,各42例。对照组采用常规清创换药治疗,于常规治疗基础上,观察组采用清毒百炎消外敷治疗。比较两组血管内皮生长因子(VEGF)、炎性因子指标、创面面积、创面愈合率、并发症及不良反应。结果治疗后两组VEGF水平均高于治疗前,C-反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)水平均低于治疗前,且观察组VEGF水平高于对照组,CRP、PCT、TNF-α水平低于对照组,差异有统计学意义(P<0.05);治疗后两组创面面积均小于治疗前,且观察组小于对照组,创面愈合率高于对照组,差异有统计学意义(P<0.05);观察组并发症总发生率低于对照组,差异有统计学意义(P<0.05);治疗期间两组均未发生局部与全身不良反应,未出现过敏现象。结论急慢性创面患者采用清毒百炎消外敷能够提高VEGF水平,提升创面愈合率,降低CRP、PCT、TNF-α水平,缩小创面面积,减少并发症的发生,临床应用安全可靠。Objective To study the application of external application of Qingdu Baiyanxie on the healing of acute and chronic wounds.Methods 84 patients with acute and chronic wounds treated in Jiujiang NO.1 People's Hospital from July 2021 to July 2023 were divided into two groups with 42 cases in each group according to random number table.Control group were treated with conventional debridement and dressing change,and observation group were treated with Qingdu Baiyanxiao on the basis of the control group.And then,vascular endothelial growth factor(VEGF),inflammatory factors,wound area,wound healing rate,complications and adverse reactions were compared between the two groups.Results After treatment,VEGF levels in both groups were higher than those before treatment,C-reactive protein(CRP),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)levels were lower than those before treatment,and VEGF levels in the observation group were higher than those in the control group,and CRP,PCT and TNF-αlevels were lower than those in the control group,and difference was statistically significant(P<0.05).After treatment,the wound areas of both groups were smaller than those before treatment,and that of the observation group was smaller than that of the control group,and the wound healing rate was higher than that of the control group,and difference was statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and difference was statistically significant(P<0.05).There were no local or systemic adverse reactions and allergic phenomenon in the two groups during treatment.Conclusion For patients with acute and chronic wounds,Qingdu Baiyanxiao can increase the levels of VEGF,enhance the healing rate of wounds,reduce the levels of CRP,PCT and TNF-α,reduce the area of wounds,and reduce the occurrence of complications,which is safe and reliable in clinical application.

关 键 词：急慢性创面 清毒百炎消 去腐生肌 血管内皮生长因子 创面愈合率 并发症 

分 类 号：R826.6[医药卫生—临床医学]