MRI用于胶质瘤神经重塑的研究进展  

Application advances of MRI in neural remodeling of glioma

作　　者：陈迪 张思敏 杨喜彪 月强(审校)[1] CHEN Di;ZHANG Simin;YANG Xibiao;YUE Qiang(Department of Radiology,West China Hospital of Sichuan University,Chengdu 610041,China;Huaxi MR Research Center(HMRRC),Department of Radiology,West China Hospital of Sichuan University.)

机构地区：[1]四川大学华西医院放射科,成都610041 [2]四川大学华西医院放射科华西磁共振研究中心

出　　处：《国际医学放射学杂志》2024年第4期390-395,共6页International Journal of Medical Radiology

基　　金：国家自然科学基金项目(82271961)。

摘　　要：胶质瘤是成人最常见的恶性脑肿瘤,复发率高且预后极差。神经重塑是大脑在胶质瘤生长中发生的复杂而精密的适应性反应,深入理解大脑的神经重塑对于改善胶质瘤病人生活质量,延长病人生存期具有重要意义。利用高分辨三维T1加权成像(3D T1WI)、扩散张量成像(DTI)及血氧水平依赖功能MRI(BOLD-fMRI)等技术,同时结合先进的影像分析方法可以探索胶质瘤病人结构和功能方面的可塑性及其相关机制。就不同MRI技术对胶质瘤病人结构和功能重塑的研究进行综述,并展望未来的研究方向。Glioma is the most common malignant brain tumor in adults,characterized by high recurrence rate and extremely poor prognosis.Neural remodeling is a complex and sophisticated adaptive response of the brain during gliomas growth.Understanding neural remodeling in the brain is crucial for improving the quality of life and extending the survival time of glioma patients.Utilizing high-resolution three-dimensional T1-weighted imaging(3D T1WI),diffusion tensor imaging(DTI),and blood oxygen level-dependent functional magnetic resonance imaging(BOLD-fMRI),combined with advanced imaging analysis methods,can explore the structural and functional plasticity in glioma patients and the related mechanisms.This review summarizes the research on structural and functional remodeling in glioma patients using various MRI techniques and provides an outlook on future research directions.

关 键 词：胶质瘤 磁共振成像 扩散张量成像 血氧水平依赖 神经重塑 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.41[医药卫生—诊断学]