7 T与3 T MRI对健康人脑内灰质核团铁沉积的定量比较  

Comparative quantitative analysis of iron deposition in gray matter nuclei in healthy human brains using 7 T and 3 T MRI

作　　者：裴迅 张雪 白晓燕 李雨桉 陈通 赵元宾 隋滨滨[1] PEI Xun;ZHANG Xue;BAI Xiaoyan;LI Yu’an;CHEN Tong;ZHAO Yuanbin;SUI Binbin(Tiantan Neuroimaging Center of Excellence,China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Department of Radiology,Beijing Tiantan Hospital,Capital Medical University;MR Research Collaboration Team,Siemens Healthineers)

机构地区：[1]首都医科大学附属北京天坛医院,国家神经系统临床疾病研究中心,天坛神经影像研究中心,北京100070 [2]首都医科大学附属北京天坛医院放射科 [3]西门子医疗磁共振科研合作团队

出　　处：《国际医学放射学杂志》2024年第4期418-424,共7页International Journal of Medical Radiology

基　　金：国家自然科学基金(62271061);北京市自然科学基金(L232130)。

摘　　要：目的比较在7 T与3 T场强下应用定量磁化率成像(QSM)分析正常人脑深部灰质核团铁沉积的差异。方法前瞻性招募无神经系统疾病的健康青年志愿者10例,平均年龄(22±3)岁;均行7 T及3 T MRI扫描采集QSM数据。应用STI-suite算法进行QSM后处理,手动勾画12个感兴趣区(包括双侧的红核、黑质、苍白球、壳核、尾状核头及丘脑),并测量脑灰质核团内的磁化率值。以7 T QSM上总体核团的平均磁化率值为参考,将核团分为高磁化率组和低磁化率组。采用配对t检验或Wilcoxon秩和检验比较同一核团在2种场强下QSM的磁化率差异。采用线性回归模型和Bland-Altman图分析2种不同场强下各核团定量磁化率的拟合度及一致性。结果3 T上测得的脑内灰质核团总体磁化率值高于7 T(P<0.05)。高磁化率组(红核、黑质、苍白球)各个核团以及总体结果均在3 T上测得的磁化率值高于7 T(P<0.05),低磁化率组(尾状核、壳核、丘脑)各个核团以及总体结果在2种场强下测得的磁化率值差异均无统计学意义(P>0.05)。线性回归结果显示2种场强下,核团总体磁化率值(R^(2)为0.954)及各核团的磁化率值的拟合度(R^(2)为0.803~0.936)均较好;Bland-Altman图分析显示2种场强下低磁化率组中各核团的磁化率值的一致性均较高,高于高磁化率组各核团。低磁化率组在2种场强下测得的磁化率拟合度(R2=0.995)高于高磁化率组(R^(2)=0.862);且低磁化率组在2种场强下磁化率的一致性高于高磁化率组。结论7 T与3 T场强下测得的低磁化率核团的磁化率值一致性较高,而在高磁化率核团中两者的差异较大,进行QSM评估时应注意场强对定量不同磁化率组织铁沉积的影响。Objective To compare the differences in iron deposition within deep gray matter nuclei of the normal human brain using quantitative susceptibility mapping(QSM)at 7 T and 3 T magnetic field strengths.Methods Ten healthy young volunteers without neurological diseases were prospectively recruited,with an average age of(22±3)years.QSM data were collected using 7 T and 3 T MRI scans.The STI-suite algorithm was used for QSM post-processing.Twelve regions of interest(ROIs),including the bilateral red nucleus,substantia nigra,globus pallidus,putamen,caudate nucleus head,and thalamus,were manually delineated,and the magnetic susceptibility values of the gray matter nuclei were measured.The nuclei were divided into high-susceptibility and low-susceptibility groups based on the average susceptibility value of all nuclei on 7 T QSM.Paired t-tests or Wilcoxon rank-sum tests were used to compare the susceptibility differences of the same nuclei at the two magnetic field strengths.Linear regression models and Bland-Altman plots were used to analyze the fit and consistency of quantitative susceptibility values of different nuclei at the two magnetic field strengths.Results The overall magnetic susceptibility values of the gray matter nuclei measured at 3 T were higher than those at 7 T(P<0.05).In the high-susceptibility group(red nucleus,substantia nigra,globus pallidus),the susceptibility values of each nucleus and the overall results measured at 3 T were higher than those at 7 T(P<0.05).In the low-susceptibility group(caudate nucleus,putamen,thalamus),there was no statistically significant difference in susceptibility values between the two field strengths for each nucleus and the overall results(P>0.05).Linear regression results showed a good fit for overall susceptibility values of nuclei(R^(2)=0.954)and susceptibility values of each nucleus(R^(2)=0.803-0.936)at the two field strengths.Bland-Altman plot analysis showed higher consistency in susceptibility values of each nucleus in the low-susceptibility group compared to th

关 键 词：磁共振成像 定量磁化率成像 铁沉积 灰质核团 超高场强 

分 类 号：R445.2[医药卫生—影像医学与核医学]