CT影像组学可辅助诊断慢性乙型肝炎肝纤维化  

Diagnostic value of CT imaging in hepatic fibrosis of chronic hepatitis B patients

作　　者：赫晓磊[1] 王俊[1] 王艳[1] HE Xiaolei;WANG Jun;WANG Yan(Radiological Imaging Center,Xinjiang Uygur Autonomous Region People's Hospital,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院放射影像中心,新疆乌鲁木齐830001

出　　处：《分子影像学杂志》2024年第7期732-735,共4页Journal of Molecular Imaging

基　　金：新疆维吾尔自治区人民医院院内项目基金(20230118)。

摘　　要：目的 探讨CT影像组学对慢性乙型肝炎(CHB)肝纤维化的诊断价值。方法 选取新疆维吾尔自治区人民医院于2023年1~10月收治的210例CHB患者为研究对象。根据患者是否发生肝纤维划分为无纤维化组(n=137)和合并纤维化组(n=73)。所有患者均接受CT平扫+增强扫描,应用Shukun Radiomics V94软件自每张CT图像的感兴趣区域内提取不同的CT影像组学特征。将入组患者划分为训练集(n=147)和验证集(n=63),通过LASSO及Logistic回归分析筛选并建立CHB患者肝纤维化的诊断模型;采用ROC曲线评价模型性能。结果 提取的1227个定量影像特征参数通过LASSO降维筛选后共保留了23个具有预测性能的组学特征用于构建CHB患者肝纤维化诊断模型,训练集的曲线下面积、准确性、敏感度和特异度分别为0.851、0.789、0.792、0.735;验证集的曲线下面积、准确性、敏感度和特异度分别为0.774、0.733、0.751、0.703。结论 通过CT影像组学特征辅助诊断CHB患者发生肝纤维化具有一定临床价值。Objective To evaluate the diagnostic value of CT imagomics in hepatic fibrosis in patients with chronic hepatitis B(CHB).Methods A total of 210 patients with CHB admitted to Xinjiang Uygur Autonomous Region People's Hospital from January to October in 2023 were selected as the study subjects.Patients were divided into non-fibrosis group(n=137)and fibrosis group(n=73).All patients underwent CT plain scan+enhanced scan.Shukun Radiomics V 94 software was used to extract different CT imagomics features from the region of interest of each CT image,including texture feature,shape feature,filter feature,density feature,etc.The enrolled patients were divided into training set(n=147)and validation set(n=63),and the diagnostic model of liver fibrosis in CHB patients was screened and established by LASSO and Logistic regression analysis.The performance of the model was evaluated using the ROC curve.Results After LASSO screening,23 of the 1227 extracted quantitative image features were retained to construct the diagnostic model of liver fibrosis in CHB patients.The AUC,accuracy,sensitivity,and specificity of the training set were 0.851,0.789,0.792,and 0.735,respectively;The AUC,accuracy,sensitivity,and specificity of the validation set were 0.774,0.733,0.751,and 0.703,respectively.Conclusion The CT image omics features show clinical significance in the assessment of liver fibrosis in patients with CHB.

关 键 词：慢性乙型肝炎 肝纤维化 CT影像组学 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学] R816.5