Establishment of abdominal aortocaval fistula in adenine-induced renal failure rats  

作　　者：张艺斐 ZHANG Yifei(Shandong Med Sci Acad,Shandong Ist Med Univ,Jinan 250000)

机构地区：[1]Shandong Med Sci Acad,Shandong 1st Med Univ,Jinan 250000

出　　处：《China Medical Abstracts(Internal Medicine)》2024年第2期115-116,共2页中国医学文摘（内科学分册（英文版）

摘　　要：Objective To explore the construction of abdominal aortocaval fistula(ACF)model in adenine-induced renal failure rats,and to provide a suitable animal model for subsequent mechanism and intervention researches.Methods Adult female Sprague-Dawley rats(250-300 g)were fed with 0.75%adenine diet(renal failure group,n=60)and the same diet without adenine(control group,n=10)for 4 weeks,and the rats were randomly grouped by block randomization method with a ratio of 6:1.Thirty rats in the renal failure group were randomly selected by block randomization method at a ratio of 1:1 to undergo laparotomies to establish ACF models(renal failure+ACF group).The serum creatinine,blood urea nitrogen detection and Masson staining were used to evaluate the establishment of renal failure model.Small animal ultrasound imaging system was applied to verify the successful construction of the ACF model.After 6 weeks of ACF observation,blood samples were collected from the heart of rats,and ACF-vascular tissues were collected for pathological study(HE staining).Results At 4 weeks of feeding.

关 键 词：RATS FISTULA RENAL 

分 类 号：R692.5[医药卫生—泌尿科学]