便血方改善内痔患者临床症状的相关机制研究  

Study on the related mechanisms of Bianxue Formula in improving clinical symptoms of patients with internal hemorrhoids

作　　者：王启[1] 王华[2] 童蕾[1] 钦梦婷 WANG Qi;WANG Hua;TONG Lei;QIN Mengting(Department of Anorectal,Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing,Zhejiang 314001,China;不详)

机构地区：[1]嘉兴市中医医院肛肠科,浙江嘉兴314001 [2]嘉兴市中医医院妇科

出　　处：《中华全科医学》2024年第7期1227-1229,1238,共4页Chinese Journal of General Practice

基　　金：浙江省中医药科技计划项目(2022ZB349)。

摘　　要：目的为提高内痔临床治疗水平,探索科学有效的中西医结合治疗途径,本研究探讨便血方用于改善内痔患者临床症状的疗效。方法选取2020年1月—2023年12月嘉兴市中医医院肛肠科收治的150例Ⅰ、Ⅱ度内痔患者为研究对象,采用随机数表法分为对照组(75例)和观察组(75例)。对照组予以复方角菜酸酯栓治疗,观察组在复方角菜酸酯栓基础上增加便血方治疗。比较患者治疗前后便血、坠痛及黏膜状态等临床症状改善情况,评价临床疗效水平,检测血清血管内皮因子和炎症因子含量变化,观察治疗期间药物不良反应。结果观察组治疗后便血评分、坠痛评分和痔核黏膜状态评分均低于对照组(P<0.001)。观察组内痔治疗总有效率[93.33%(70/75)]显著高于对照组[74.67%(56/75),P<0.05]。观察组治疗后血清内皮素-1(EF-1)、细胞间黏附因子-1(ICAM-1)、血管细胞黏附因子-1(VCAM-1)和内皮一氧化氮合酶(eNOS)等血管内皮因子水平均低于对照组(P<0.001)。观察组治疗后血清IL-1β、IL-6、IL-8和TNF-α等炎症因子含量均低于对照组(P<0.001)。结论便血方联合复方角菜酸酯栓治疗可有效缓解内痔患者临床症状,提高临床疗效,临床症状的改善可能与便血方抑制血管内皮损伤和炎症反应的相关性。Objective In order to improve the clinical treatment level of internal hemorrhoids and explore a scientifically effective combination of traditional Chinese and Western medicine treatment approach,this study explores the clinical effect and pharmacological mechanism of Bianxue Formula to improve clinical symptoms in patients with internal hemorrhoids.Methods A total of 150 patients with gradeⅠandⅡinternal hemorrhoids admitted to the Department of Anorectal of Jiaxing Hospital of Traditional Chinese Medicine from January 2020 to December 2023 were selected as the research objects.According to the random number table method,they were divided into the control group(75 cases)and the observation group(75 cases).The control group was treated with compound cabbage ester suppository,while the observation group was treated with an additional formula for constipation and bleeding on the basis of compound carrageenan suppositories.The improvement of clinical symptoms such as rectal bleeding,pain,and hemorrhoid mucosal status before and after treatment were observed,the level of clinical efficacy was evaluated,the changes in serum vascular endothelial factor and inflammatory factor levels were detected,and the adverse drug reactions during treatment were followed up.Results After treatment,the observation group had lower scores for rectal bleeding,falling pain,and hemorrhoid mucosal status compared to the control group(P<0.001).The overall effective rate of hemorrhoid treatment in the observation group[93.33%(70/75)]was higher than the control group[74.67%(56/75),P<0.05].The levels of vascular endothelial factors in serum such as endothelin 1(EF-1),intercellular adhesion factor-1(ICAM-1),vascular cell adhesion factor-1(VCAM-1),and endothelial nitric oxide synthase(eNOS)in the observation group after treatment was lower than the control group(P<0.001).The content of inflammatory factors in serum such as IL-1β,IL-6,IL-8,and TNF-αin the observation group after treatment were lower than the control group(P<0.001).Conclusio

关 键 词：内痔 复方角菜酸酯栓 便血方 临床症状 血管内皮损伤 药理机制 

分 类 号：R657.1[医药卫生—外科学] R243[医药卫生—临床医学]