益气养阴方治疗系统性红斑狼疮有效性和安全性的meta分析  

Efficacy and safety of Yiqi Yangyin Decoction in treating systemic lupus erythematosus:a meta-analysis

作　　者：张强[1] 邓伟哲[1] 伊世华 邵英子 王振宇[4] 路秀云[4] ZHANG Qiang;DENG Weizhe;YI Shihua;SHAO Yingzi;WANG Zhenyu;LU Xiuyun(Rheumatology and Traditional Chinese Medicine Department,the 962nd Hospital of the PLA,Harbin,Heilongjiang 150048,China;不详)

机构地区：[1]中国人民解放军联勤保障部队第九六二医院中医风湿科,黑龙江哈尔滨150048 [2]黑龙江省中医药科学院肾病三科,黑龙江哈尔滨150036 [3]黑龙江省中医药科学院检验科 [4]哈尔滨医科大学附属第二医院中医科,黑龙江哈尔滨150086

出　　处：《中华全科医学》2024年第7期1239-1245,共7页Chinese Journal of General Practice

基　　金：黑龙江省卫生健康委科研课题(20222121011102);黑龙江省医学发展基金会项目(2023QY003)。

摘　　要：目的中医经典方在风湿性疾病的应用是近年研究的热点,系统性红斑狼疮(SLE)在我国拥有庞大的患者基数,中西医结合治疗SLE的疗效存在争议。本研究通过荟萃分析的方法探讨益气养阴方治疗系统性红斑狼疮有效性和安全性。方法检索PubMed、Medline、EMbase、Cochrane Library、Web of science、CBM、Wangfang、CNKI和VIP,检索时间为从建库至2023年11月26日。纳入益气养阴方治疗SLE的随机对照试验研究,试验组接受益气养阴方联合西药治疗,对照组接受西药治疗。应用EndNote 20.0进行筛选和管理文献。提取数据后应用RevMan 5.4进行质量评价和分析。应用Stata 15.0进行敏感性和发表偏倚分析。结果纳入24项研究,共1991例患者,其中试验组1051例,对照组940例。试验组的总有效率(OR=4.35,95%CI:3.11~6.11)高于对照组,不良反应发生率(OR=0.17,95%CI:0.11~0.26)低于对照组,差异均有统计学意义(P<0.05)。试验组的中医证候积分、系统性红斑狼疮活动指数(SLEDAI)、ds-DNA转阴率、C3水平、24小时尿蛋白定量、糖皮质激素维持量均优于对照组,差异均有统计学意义(P<0.05),试验组的ANA转阴率略高于对照组,但差异无统计学意义(P>0.05)。结论应用益气养阴方治疗SLE可提高临床总有效率,降低不良反应发生率,在各项转归均有良好的效果。Objective The application of classic Chinese medicine in rheumatic diseases has been a prominent research focus.Systemic lupus erythematosus(SLE)has a significant patient population in China.The efficacy of integrated Chinese and Western medicine in the treatment of SLE remains controversial.This study explores the effectiveness and safety of the Yiqi Yangyin Decoction in the treatment of systemic lupus erythematosus through meta-analysis.Methods A comprehensive search was conducted on multiple databases including PubMed,Medline,EMbase,Cochrane Library,Web of Science,CBM,Wangfang,CNKI,and VIP from the establishment of the database to November 26,2023.The scope of the search was limited to randomized controlled trial studying the efficacy of Yiqi Yangyin Decoction in the treatment of SLE.The experimental group received Yiqi Yangyin Decoction in combination with Western medicine,while the control group received only Western medicine.The retrieved literature was filtered and managed using EndNote 20.0.Data extraction and quality evaluation were performed using RevMan 5.4.Sensitivity analysis and publication bias analysis were conducted using Stata 15.0.Results A total of 24 studies were conducted,including 1051 patients in the experimental group and 940 patients in the control group.The experimental group showed a higher total effective rate compared to the control group(OR=4.35,95%CI:3.11-6.11).Additionally,the experimental group had a lower incidence of adverse reactions compared to the control group(OR=0.17,95%CI:0.11-0.26).These differences were statistically significant(P<0.05).The experimental group showed better scores in traditional Chinese medicine syndrome,systemic lupus erythematosus disease activity index,ds-DNA negative conversion rate,complement3,24 hour urinary protein quantity,and glucocorticoid maintenance dosage compared to the control group,with all differences being statistically significant(P<0.05).The ANA negative conversion rate was slightly higher in the experimental group,but the difference

关 键 词：益气养阴方 系统性红斑狼疮 中西医结合治疗 META分析 

分 类 号：R593.241[医药卫生—内科学] R256[医药卫生—临床医学]