血清BNP TFC CO Scr水平与收缩功能障碍性心力衰竭患者短期预后关系研究  

Relationship between Serum BNP TFC CO and Scr Levels and Short-Term Prognosis in Patients with Systolic Heart Failure

作　　者：董君慧 赵晨 陈文馨 王福华[2] 郭靖涛[2] DONG Junhui;ZHAO Chen;CHEN Wenxin(Graduate School,Chengde Medical University,Hebei Chengde 067000,China)

机构地区：[1]承德医学院研究生学院,河北承德067000 [2]河北省承德市中心医院心血管内科,河北承德067000

出　　处：《河北医学》2024年第7期1197-1201,共5页Hebei Medicine

基　　金：2020年承德市科学技术研究与发展计划项目,(编号:202006A024)。

摘　　要：目的:探究血清BNP、TFC、CO、Scr等容量负荷评估指标与收缩功能障碍性心力衰竭患者短期预后的关系。方法:连续选取2021年11月至2023年1月于承德市中心医院心血管内科住院的收缩功能障碍性(LVEF<50%)心力衰竭患者93例,记录患者出院后90d内出现心衰症状和体征加重、心血管性再就诊和(或)再住院以及心因性死亡等情况。根据预后情况分为两组:预后良好组和预后不良组。结果:共完成随访93例患者,预后不良31人。预后不良组患者的LVEF、CO、冠心病患病率均低于预后良好组(P<0.05);预后不良组患者的BNP、cTnI、TFC、Scr均高于预后良好组(P<0.05)。其中容量负荷评估指标BNP、TFC、CO、Scr是收缩功能障碍性心力衰竭患者出院后90天内发生不良预后的影响因素(P<0.05)。结论:容量负荷评估指标BNP、TFC、CO、Scr是收缩功能障碍性心力衰竭患者短期预后的影响因素,对其短期预后或可具有预测作用,对收缩功能障碍性心力衰竭患者临床治疗具有指导意义。Objective:To explore the relationship between serum BNP,TFC,CO,Scr and the short-term prognosis of patients with systolic dysfunction heart failure.Methods:A total of 93 patients with systolic dysfunction(LVEF<50%)heart failure admitted to the cardiovascular Department of Chengde Central Hospital from November 2021 to January 2023 were selected.Exacerbation of signs and symptoms of heart failure,cardiovascular re-visits and/or re-hospitalization,and cardiac death were recorded within 90 days after discharge.They were divided into two groups according to the prognosis:good prognosis group and bad prognosis group.Results:A total of 93 patients were followed up,31 of whom had poor prognosis.LVEF,CO and the prevalence of coronary atherosclerotic heart disease in the poor prognosis group was lower than that in the good prognosis group,and the difference was statistically significant(P<0.05).BNP,cTnI,TFC and Scr in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant(P<0.05).Among them,BNP,TFC,CO and Scr are the factors influencing the adverse prognosis of patients with systolic dysfunction heart failure within 90 days after discharge(P<0.05).Conclusion:Volume load evaluation indexes BNP,TFC,CO and Scr are influential factors for the short-term prognosis of patients with systolic dysfunction heart failure,and may have a predictive effect on their prognosis,and have guiding significance for clinical treatment of patients with heart failure.

关 键 词：收缩功能障碍性心力衰竭 心输出量 血清肌酐 短期预后 

分 类 号：R541.6[医药卫生—心血管疾病]