^(18)F-FDG PET/CT在IgG4相关心血管疾病中的应用进展  

Research progress of^(18)F-FDG PET/CT in IgG4 related cardiovascular diseases

作　　者：宋乐乐 邱永康 张潇月 康磊[1] Song Lele;Qiu Yongkang;Zhang Xiaoyue;Kang Lei(Department of Nuclear Medicine,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院核医学科,北京100034

出　　处：《国际放射医学核医学杂志》2024年第4期257-261,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金面上项目(82171970);北京市杰出青年科学基金(JQ21025);北京市科学技术委员会首都临床特色应用研究项目(Z221100007422027)。

摘　　要：免疫球蛋白G4相关疾病(IgG4-RD)是一种全身炎症性疾病,通常累及多个器官。IgG4相关心血管疾病(IgG4-RCVD)包括IgG4相关主动脉病变、IgG4相关冠状动脉病变、IgG4相关肺动脉病变和IgG4相关心包炎。IgG4-RCVD受累部位IgG4阳性浆细胞聚集并高表达葡萄糖转运蛋白。^(18)F-氟脱氧葡萄糖(FDG)PET/CT可以基于IgG4-RCVD患者病变部位的代谢程度在全身范围内评估血管炎症的范围和程度,在诊断和定量评估IgG4-RCVD血管炎症、指导活检部位选择以及疗效监测等方面起到关键作用。笔者对^(18)F-FDG PET/CT在IgG4-RCVD应用中的进展进行综述,以期为临床医师通过^(18)F-FDG PET/CT诊断IgG4-RCVD提供参考。Immunoglobulin G4-related disease(IgG4-RD)is a type of systemic inflammatory diseases that often affect multiple organs.IgG4-related cardiovascular disease(IgG4-RCVD)includes IgG4-related aortic disease,IgG4-related coronary artery disease,IgG4-related pulmonary artery disease,and IgG4-related pericarditis.IgG4-positive plasma cells accumulate and exhibit high expression of glucose transport proteins at the site of IgG4-RCVD involvement.^(18)F-fluorodeoxyglucose(FDG)PET/CT can assess the extent and degree of vascular inflammation on a systemic scale by evaluating the metabolic activity of lesions in IgG4-RCVD patients.It plays a pivotal role in diagnosing and quantitatively assessing IgG4-RCVD vascular inflammation,aiding in the selection of biopsy sites,and monitoring treatment efficacy.The authors conducted a comprehensive review of the advancements in the utilization of^(18)F-FDG PET/CT for IgG4-RCVD,aiming to furnish clinicians with a valuable reference for diagnosing IgG4-RCVD through the application of^(18)F-FDG PET/CT.

关 键 词：氟脱氧葡萄糖F18 正电子发射断层显像术 体层摄影术 X线计算机 免疫球蛋白G4相关疾病 免疫球蛋白G4相关心血管疾病 

分 类 号：R817.4[医药卫生—影像医学与核医学] R54[医药卫生—放射医学]