光对秋水仙碱稳定性的影响及光稳定剂筛选  

Effect of light on stability of colchicine and screening of photostabilizers

作　　者：杨国宝 董静 龚伟 杨美燕 高春生 王玉丽 杨阳 YANG Guobao;DONG Jing;GONG Wei;YANG Meiyan;GAO Chunsheng;WANG Yuli;YANG Yang(Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]军事科学院军事医学研究院,北京100850

出　　处：《军事医学》2024年第5期376-381,共6页Military Medical Sciences

基　　金：国家“重大新药创制”科技重大项目(2018ZX09711003-008-001)。

摘　　要：目的提高秋水仙碱(COL)在制剂缓释微丸中的光稳定性。方法对COL光化降解动力学进行研究,了解其降解规律,通过添加光稳定剂屏蔽光线以抑制COL发生光化降解,并考察了光稳定剂种类、颜色、用量、位置对COL缓释微丸光稳定性的影响。结果以中间独立层的方式,用载药微丸重量4%的红氧化铁作为保护层制备的缓释微丸光照10 d,COL光化降解产物含量未见增长。结论COL缓释微丸中使用红氧化铁作为光稳定剂,能够有效避免COL发生光化降解。Objective To enhance the photostability of colchicine(COL)for sustained-release COL pellets.Methods The degradation was investigated by studying the photochemical degradation kinetics of COL.The impact of such physical properties of the photostabilizers as the type,color,dosage,and position on the photostability of COL in sustained-release pellets was also evaluated.Results The contents of photochemical degradation products did not increase after 10 days of light exposure to sustained-release COL pellets with red iron oxide of 4%(w/w)as the protective layer.Conclusion The findings of this study indicate that use of iron oxide as a photostabilizer in sustained-release COL pellets can significantly reduce the photochemical degradation of COL in the pellets.

关 键 词：秋水仙碱 缓释微丸 光化降解 光稳定性 光稳定剂 氧化铁 

分 类 号：R285.5[医药卫生—中药学]