Vilsmeier反应在呋虫胺合成中的应用  

Application of Vilsmeier Reaction on Synthesis of Dinotefuran

作　　者：盛国柱 牛家杰 刘瑞宾 SHENG Guo-zhu;NIU Jia-jie;LIU Rui-bin(Shandong Kangqiao Biology&Technology Co.,Ltd.,Shandong Binzhou 256500,China)

机构地区：[1]山东康乔生物科技有限公司,山东滨州256500

出　　处：《广州化工》2024年第10期60-62,共3页GuangZhou Chemical Industry

摘　　要：将Vilsmeier反应应用到呋虫胺的合成中,设计一条呋虫胺合成的全新路径。以2,5-二氢呋喃为基础原料,通过Vilsmeier反应、还原氨化、缩合三步反应得到呋虫胺,通过GC对中间体合成追踪和定性鉴定,通过HPLC、熔点和核磁仪对目标产品呋虫胺合成追踪、含量测定和结构表征,整体收率为63%。该方法具有合成路线短,工艺成本低,操作简单等优点,对于呋虫胺的合成及工业生产具有重要意义。A new route about synthesis of dinotefuran was designed on application of Vilsmeier reaction.It was obtained by Vilsmeier reaction,reductive amination and condensation reaction with 2,5-dihydrofuran as material.And the reaction for synthesis of intermediates was monitored and identified by GC.Dinotefuran was identified and characterized by HPLC,melting point and NMR.The whole yield of dinotefuran is 63%.The method is better than tranditional route.Its has short synthetic route,low cost on process,easily operating.It is essential for synthesis of dinotefuran.

关 键 词：2 5-二氢呋喃 Vilsmeier反应 3-氨甲基四氢呋喃 呋虫胺 

分 类 号：TQ453[化学工程—农药化工]