老年COPD并呼吸衰竭血清CHE表达检测及其与动脉血PaO2的相关性研究  

Serum Cholinesterase(CHE)Expression and Its Correlation with Arterial Blood PaO2 in Elderly Patients with COPD and Respiratory Failure

作　　者：刘欣 高婧[1] 杨美菊[1] LIU Xin;GAO Jing;YANG Mei-ju(he First People's Hospital of Shangqiu City,Shangqiu 476000,Henan Province,China)

机构地区：[1]商丘市第一人民医院,河南商丘476000

出　　处：《罕少疾病杂志》2024年第7期35-36,39,共3页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20191481)。

摘　　要：目的分析老年慢性阻塞性肺疾病(COPD)并呼吸衰竭患者血清胆碱酯酶(CHE)表达检测及其与动脉血动脉血氧分压(PaO2)的相关性。方法选取2021年6月~2023年6月收治的100例COPD老年患者为COPD组,以是否合并呼吸衰竭为依据,将COPD组分为合并组(合并呼吸衰竭)与未合并组(未合并呼吸衰竭),分别为61例、39例。随访时间截止为患者出院时间,以随访结局是否为死亡为依据,将合并组分为存活组(44例)与死亡组(17例);以病情程度为依据,将合并组分为急性加重组(11例)与稳定组(50例),同期选取50例健康体检者为对照组。回顾性分析入组者临床资料,记录年龄、性别、病程、治疗情况、血气分析、病情程度、CHE水平及随访结局,对比对照组、合并组与未合并组、稳定组与急性加重组、死亡组与存活组PaO2、CHE水平,以Pearson法分析合并组患者CHE与PaO2的相关性。结果合并组与未合并组PaO2、CHE水平较对照组更低(P<0.05);合并组PaO2、CHE水平较未合并组更低(P<0.05);急性加重组PaO2、CHE水平较稳定组更低(P<0.05);死亡组PaO2、CHE水平较存活组更低(P<0.05);Pearson分析显示,合并组血清CHE水平与PaO2呈正相关(r=0.533,P<0.05)。结论CHE在老年COPD并呼吸衰竭患者血清中低表达,与PaO2呈正相关,检测CHE可准确反映患者病情程度,并可用于预后评估。Objective To analyze the serum cholinesterase(CHE)expression test and its correlation with arterial blood partial pressure of oxygen(PaO2)in elderly patients with chronic obstructive pulmonary disease(COPD)and respiratory failure.Methods One hundred elderly patients with COPD admitted from June 2021 to June 2023 were selected as the COPD group,and the COPD group was divided into the combined group(combined with respiratory failure)and the uncomplicated group(uncomplicated with respiratory failure)on the basis of whether or not they were combined with respiratory failure,which were 61 cases and 39 cases,respectively.The follow-up time was cut off at the time of patients'discharge from the hospital,and the combined group was divided into the survival group(44 cases)and the death group(17 cases)based on whether the follow-up outcome was death or not;the combined group was divided into the acute plus group(11 cases)and the stable group(50 cases)based on the degree of the disease,and 50 healthy medical checkups were selected as the control group at the same time.The clinical data of the enrolled patients were retrospectively analyzed,and age,gender,duration of disease,treatment,blood gas analysis,degree of disease,CHE level and follow-up results were recorded.PaO2 and CHE levels were compared between the control group,the combined group and the un-combined group,the stabilized group and the acute plus group,and the dead group and the survived group,and the correlation between CHE and PaO2 of the patients in the combined group was analyzed by Pearson's method.Results PaO2 and CHE levels were lower in the combined group compared with the non-combined group(P<0.05);PaO2 and CHE levels were lower in the combined group compared with the non-combined group(P<0.05);PaO2 and CHE levels were lower in the acute plus group compared with the stabilized group(P<0.05);and PaO2 and CHE levels were lower in the death group compared with the surviving group(P<0.05);Pearson analysis showed that serum CHE level was positively correlated

关 键 词：慢性阻塞性肺疾病 动脉血氧分压 呼吸衰竭 相关性 胆碱酯酶 

分 类 号：R563[医药卫生—呼吸系统]