卵巢癌组织LGR4蛋白表达与临床病理特征、术后复发的关系研究  

Study on the Relationship between Expression of LGR4 Protein and Clinicopathological Characteristics,Postoperative Recurrence in Ovarian Cancer

作　　者：杨平 赵帅华[2] YANG Ping;ZHAO Shuai-hua(Department of Pathology,the Third People's Hospital of Anyang City,Anyang 455000,Henan Province,China;Department of Pathology,Anyang District Hospital of Puyang City,Anyang 455000,Henan Province,China)

机构地区：[1]安阳市第三人民医院病理科,河南安阳455000 [2]濮阳市安阳地区医院病理科,河南安阳455000

出　　处：《罕少疾病杂志》2024年第7期92-95,共4页Journal of Rare and Uncommon Diseases

摘　　要：目的探究卵巢癌组织富含亮氨酸重复序列的G蛋白耦联受体4(LGR4)蛋白表达与临床病理特征、术后复发的关系。方法选取本院2020年8月~2022年1月份收治138例行手术治疗的卵巢癌患者,采用免疫组织化学法检测癌组织和切缘正常组织LGR4蛋白表达率并比较;比较不同临床病理特征患者癌组织LGR4蛋白阳性表达率;随访1年,统计患者复发率,比较复发与未复发患者癌组织LGR4蛋白表达率;采用Cox比例风险回归模型分析卵巢癌患者术后复发的的危险因素,Pearson双变量法分析LGR4蛋白表达与术后复发的相关性。结果卵巢癌患者癌组织LGR4蛋白阳性表达率高于切缘正常组织(P<0.05),且TNM分期Ⅲ期、未/低分化、最大肿瘤直径≥4 cm、有淋巴结转移患者癌组织LGR4蛋白阳性表达率分别高于TNM分期I~II期、中/高分化、最大肿瘤直径<4 cm、无淋巴结转移患者(P<0.05);随访结束时有45例患者复发,复发率为36.59%,未进行靶向治疗、手术效果未达到R0、放化疗不敏感、术中肿瘤破裂、卵巢癌组织LGR4蛋白阳性表达均为卵巢癌患者术后复发的危险因素(RR=4.437、3.961、5.524、4.711、6.476,P<0.05);卵巢癌患者术后复发与LGR4蛋白表达呈正相关(r=0.416,P<0.05),LGR4蛋白阳性表达患者复发率高于LGR4蛋白阴性表达患者(=19.295,P<0.001)。结论卵巢癌患者癌组织LGR4蛋白阳性表达率高于切缘正常组织,TNM分期Ⅲ期、未/低分化、有淋巴结转移及癌组织LGR4蛋白阳性表达均为卵巢癌术后复发的危险因素,且卵巢癌术后复发与LGR4蛋白表达呈正相关。Objective To explore the relationship between leucine-rich G protein coupled receptor 4(LGR4)protein expression and clinicopathologic features and postoperative recurrence in ovarian cancer.Methods A total of 138 ovarian cancer patients admitted to our hospital for surgical treatment from August 2020 to January 2022 were selected.The expression rate of LGR4 protein in cancer tissue and normal incisal margin tissues was detected by immunohistochemistry and compared.The positive expression rates of LGR4 protein in cancer tissues of patients with different clinicopathological features were compared.The patients were followed up for 1 year,and the recurrence rate was calculated,and the LGR4 protein expression rates were compared between patients with recurrence and those without recurrence.Cox proportional risk regression model was used to analyze the risk factors of postoperative recurrence in ovarian cancer patients,and Pearson bivariate method was used to analyze the correlation between LGR4 protein expression and postoperative recurrence.Results The positive expression rate of LGR4 protein in ovarian cancer tissues was higher than those in normal incisal tissue(P<0.05),and the positive expression rates of LGR4 protein in cancer tissues of patients with TNM stageⅢ,undifferentiated/poorly differentiated,maximum tumor diameter≥4 cm,and lymph node metastasis were higher than those of patients with TNM stage I-II,moderate/highly differentiated,maximum tumor diameter<4 cm,and no lymph node metastasis(P<0.05),respectively.At the end of follow-up,45 patients had recurrence,and the recurrence rate was 36.59%.Failure to undergo targeted therapy,failure to achieve R0 surgical results,insensitivity to radiotherapy and chemotherapy,intraoperative tumor rupture and positive expression of LGR4 protein in ovarian cancer tissues were all risk factors for postoperative recurrence of ovarian cancer patients(RR=4.437,3.961,5.524,4.711,6.476,P<0.05).Postoperative recurrence of ovarian cancer patients was positively correlated wit

关 键 词：卵巢癌 G耦联蛋白受体4 临床病理特征 复发 

分 类 号：R711.75[医药卫生—妇产科学]