血清AMH及性激素水平与大学生体检多囊卵巢综合征的相关性  

Correlation between Serum AMH and Sex Hormone Levels and Polycystic Ovary Syndrome in College Students

作　　者：王静[1] 赫松涛 陈刚[2] WANG Jing;HE Song-tao;CHEN Gang(Clinical Laboratory of Zhengzhou University Hospital,Zhengzhou 450000,Henan Province,China;Clinical Laboratory of the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州大学医院检验科,河南郑州450000 [2]郑州大学第一附属医院检验科,河南郑州450000

出　　处：《罕少疾病杂志》2024年第7期96-98,共3页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划项目(LHGJ20200907)。

摘　　要：目的分析血清抗缪勒氏管激素(AMH)及性激素水平与大学生体检多囊卵巢综合征(PCOS)的相关性。方法收集2021年3月-2023年11月我院体检确诊为PCOS的80例大学生临床资料作为观察组,另外收集同时期体检的128例非PCOS人群临床资料为对照组。比较两组一般资料、AMH及性激素水平;受试者操作特征曲线(ROC)下面积(AUC)评价AMH及性激素6项对PCOS的预测效能;皮尔森相关性分析AMH水平与性激素水平的相关关系。结果两组年龄、身高、体重、体质量指数比较差异无统计学意义(P>0.05)。PCOS组促卵泡生成素、促黄体生成素、雌二醇、睾酮、催乳素均高于非PCOS组,孕酮低于非PCOS组,差异显著,P<0.05。将PCOS=1,非PCOS=0作为因变量,AMH、性激素6项作为自变量,进行ROC曲线分析,结果显示,AMH及性激素6项均对PCOS有良好的预测价值,AUC分别为0.946、0.924,灵敏度分别为0.850、0.850,特异度为0.977、0.891。但AMH联合性激素6项的预测效能较高,AUC最大,为0.997,灵敏度为0.988,特异度为0.977。AMH的预测阈值为7.975ng/mL。PCOS患者血清AMH水平与促黄体生成素、雌二醇呈显著正相关关系(P<0.05),与促卵泡生成素、睾酮、孕酮、催乳素的相关关系不显著(P>0.05)。结论AMH及性激素水平在大学生体检确认为PCOS血清中异常表达,血清AMH及性激素水平可能与PCOS具有一定相关性,AMH联合性激素6项目对PCOS有良好的评估价值,AMH与促黄体生成素、雌二醇呈显著正相关关系。Objective To analyze the correlation between serum levels of anti-Muller's hormone(AMH)and sex hormone and polycystic ovary syndrome(PCOS).Methods The clinical data of 80 college students diagnosed with PCOS during physical examination in our hospital from March 2021 to November 2023 were collected as the observation group,and the clinical data of 128 non-PCOS patients during physical examination during the same period were collected as the control group.General data,AMH and sex hormone levels were compared between the two groups.The area under receiver operating characteristic curve(ROC)(AUC)was used to evaluate the predictive efficacy of AMH and sex hormones in PCOS.The correlation between AMH level and sex hormone level was analyzed by Pearson correlation.Results There were no significant differences in age,height,weight and body mass index between the two groups(P>0.05).Follicle-stimulating hormone,luteinizing hormone,estradiol,testosterone and prolactin in PCOS group were higher than those in non-PCOS group,and progesterone was lower than that in non-PCOS group,the difference was significant(P<0.05).With PCOS=1,non-PCOS=0 as dependent variables,and AMH and sex hormone as independent variables,ROC curve analysis was performed.The results showed that AMH and sex hormone had good predictive value for PCOS,with AUC of 0.946 and 0.924 and sensitivity of 0.850 and 0.850,respectively.The specificity was 0.977 and 0.891.However,AMH combined with sex hormone 6 had higher predictive efficacy,with the largest AUC(0.997),sensitivity(0.988)and specificity(0.977).The predicted threshold of AMH was 7.975 ng/mL.Serum AMH level in PCOS patients was significantly positively correlated with luteinizing hormone and estradiol(P<0.05),but was not significantly correlated with follicle-stimulating hormone,testosterone,progesterone and prolactin(P>0.05).Conclusion The abnormal expression of AMH and sex hormone levels in serum of PCOS was confirmed by physical examination of college students,and the serum AMH and sex hormone levels

关 键 词：AMH 促卵泡生成素 促黄体生成素 雌二醇 孕酮 睾酮 催乳素 多囊卵巢综合征 

分 类 号：R711.75[医药卫生—妇产科学]