大剂量氨溴索联合布地奈德、阿奇霉素序贯对重症肺炎支原体肺炎患儿免疫和肺功能的影响  

The Effect of High-dose Ambroxol Combined with Budesonide and Azithromycin on Immunity and Lung Function in Children with Severe Mycoplasma Pneumoniae Pneumonia

作　　者：许院锋 刘凤娟 XU Yuan-feng;LIU Feng-juan(Pediatrics Department of Qingfeng First Hospital,Puyang 457300,Henan Province,China)

机构地区：[1]清丰第一医院儿科,河南濮阳457300

出　　处：《罕少疾病杂志》2024年第7期136-138,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的分析大剂量氨溴索联合布地奈德、阿奇霉素序贯对重症肺炎支原体肺炎患儿的效果。方法回顾性分析86例清丰第一医院就诊的重症肺炎支原体肺炎患儿的资料,根据治疗方法分为试验组和对照组,试验组和对照组各43例。对照组实施阿奇霉素序贯疗法,试验组另雾化吸入氨溴索联合布地奈德,两组患儿治疗时间均为两周。比较两组临床效果,观察两组治疗前后IL-4、IL-10、IL-18水平,比较两组肺功能指标变化及T淋巴细胞亚群CD3+、CD4+、CD8+及CD4+/CD8+水平。结果试验组治疗后临床疗效优于对照组(P<0.05);治疗后两组患者血清1L-4和1L-18均有所降低,1L-10有所提高,且试验组优于对照组(P<0.05);治疗后两组患者FVC、PEF、MVV、FEV1/FVC指标均有所提高,试验组提高幅度大于对照组(P<0.05);治疗后两组患者CD3+、CD4+、CD4+/CD8+水平均有所升高,试验组升高幅度大于对照组,CD8+水平有所降低,试验组降低降低幅度大于对照组(P<0.05)。结论大剂量氨溴索联合布地奈德、阿奇霉素序贯治疗可提高患儿免疫水平,缓解其炎性反应,并改善其肺功能指标,临床疗效较为显著。Objective To analyze the effects of high-dose ambroxol combined with budesonide and azithromycin on immunity and lung function in children with severe M.pneumoniae pneumonia.Methods Retrospectively selected 86 children with severe mycoplasma pneumonia,it was divided into test group and control group according to the treatment method,with 43 cases in each.The control group were treated with azithromycin sequential therapy,and the test group were also treated with ambroxol and budesonide aerosol inhalation.The treatment time in both groups was two weeks.The clinical effects of the two groups,observe the levels of IL-4,IL-10 and IL-18 before and after treatment in the two groups,and compare the changes of lung function indicators and the levels of CD3+,CD4+,CD8+and CD4+/CD8+in T lymphocyte subsets were compared.Results The clinical efficacy of the test group was better than that control group(P<0.05);serum IL-4 and IL-18 in both groups,IL-10 has been improved,Moreover,the test group was better than the control group(P<0.05);after treatment,the FVC,PEF,MVV,and FEV 1/FVC indexes were improved in both groups,the increase in the test group was greater than the control group(P<0.05);the CD3+,CD4+,and CD4+/CD8+levels were increased in both groups.The increase in test group was greater than that control group.The CD8+levels have decreased somewhat,and the decrease in test group was greater than control group(P<0.05).Conclusion High-dose ambroxol combined with budesonide and azithromycin can improve the immune level of children,improve their pulmonary function index,and alleviate their inflammatory response,with significant clinical effect.

关 键 词：氨溴索 布地奈德 阿奇霉素 儿童支原体肺炎 肺功能 

分 类 号：R725.6[医药卫生—儿科]