血清anti-β2GPI、FSTL1、PD-1对系统性红斑狼疮免疫功能、疾病活动度的影响  

Effects of Serum Anti-β2GPI,FSTL1,PD-1 on Immune Function and Disease Activity in Patients with Systemic Lupus Erythematosus

作　　者：王晓娟[1] 邢广栋[1] WANG Xiao-juan;XING Guang-dong(Clinical Laboratory,Puyang People’s Hospital,Puyang 457000,Henan Province,China)

机构地区：[1]濮阳市人民医院检验科,河南濮阳457000

出　　处：《罕少疾病杂志》2024年第7期142-144,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探究血清抗β2糖蛋白I抗体(anti-β2GPI)、卵泡抑素样蛋白(FSTL1)、程序性死亡受体1(PD-1)对系统性红斑狼疮(SLE)患者免疫功能、疾病活动度的影响。方法选取我院2019年1月~2022年6月SLE患者113例作为观察组,另选取同期健康体检者105例作为对照组。比较两组、不同疾病活动度患者血清anti-β2GPI、FSTL1、PD-1水平,评价各血清指标与疾病活动度的关系,并根据观察组血清表达水平分为高表达者、低表达者,对比两者免疫功能(CD4+、CD8+、CD4+/CD8+),分析各血清指标与免疫功能相关性。结果观察组血清anti-β2GPI、FSTL1、PD-1高于对照组(P<0.05);血清anti-β2GPI、FSTL1、PD-1高表达患者CD4+、CD4+/CD8+低于低表达患者,CD8+高于低表达患者(P<0.05);血清anti-β2GPI、FSTL1、PD-1与CD4+、CD4+/CD8+呈负相关,与CD8+呈正相关(P<0.05);血清anti-β2GPI、FSTL1、PD-1水平随疾病活动度增加呈升高趋势,且重度活动患者>中度活动患者>轻度活动患者>病情稳定患者(P<0.05);血清anti-β2GPI、FSTL1、PD-1与疾病活动度显著相关(P<0.05)。结论血清anti-β2GPI、FSTL1、PD-1高表达可能参与SLE患者细胞免疫功能紊乱、疾病活动度加重的发生过程。Objective To investigate the effects of serum anti-β2 glycoprotein I antibody(anti-β2GPI),follicle inhibin-like protein(FSTL1)and programmed death receptor 1(PD-1)on immune function and disease activity in patients with systemic lupus erythematosus(SLE).Methods From January 2019 to June 2022 in our hospital,113 cases of SLE patients were selected as the observation group,and 105 healthy medical examinees were selected as the control group.Compareing the serum anti-β2GPI,FSTL1,PD-1 levels of the two groups and patients with different disease activities,and evaluating the relationship between each serum index and disease activity.According to the serum expression level of the observation group,they were divided into high-expressors and low-expressors.The immune functions(CD4+,CD8+,CD4+/CD8+)of the two were compared,and the correlation between each serum index and immune function was analyzed.Results The serum anti-β2GPI,FSTL1,and PD-1 in the observation group were higher than those in the control group(P<0.05);patients with high expression of serum anti-β2GPI,FSTL1 and PD-1 had lower CD4+,CD4+/CD8+than low-expression patients,and CD8+was higher than low-expression patients(P<0.05);serum anti-β2GPI,FSTL1,PD-1 was negatively correlated with CD4+,CD4+/CD8+,and positively correlated with CD8+(P<0.05);serum levels of anti-β2GPI,FSTL1 and PD-1 showed an increasing trend with the increase of disease activity,and patients with severe activity>patients with moderate activity>patients with mild activity>patients with stable condition(P<0.05);serum anti-β2GPI,FSTL1,and PD-1 were significantly correlated with disease activity(P<0.05).Conclusion The high expression of serum anti-β2GPI,FSTL1,and PD-1 may be involved in the occurrence of cellular immune dysfunction and increased disease activity in patients with SLE.

关 键 词：抗Β2糖蛋白I抗体 卵泡抑素样蛋白 程序性死亡受体1 系统性红斑狼疮 免疫功能 疾病活动度 

分 类 号：R593.241[医药卫生—内科学]