心外膜脂肪在心房心肌病和心房重构中作用的研究进展  

Advances in the role of epicardial fat in atrial cardiomyopathy and atrial remodeling

作　　者：李梓溪 古佳茹 国真 李影 夏雪 刘斌(综述)[1] 孙欢(审校)[1] LI Zixi;GU Jiaru;GUO Zhen;LI Ying;XIA Xue;LIU Bin;SUN Huan(Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun 130033,China;Norman Bethune Health Science Center of Jilin University,Changchun 130033,China;Department of Cardiology,Qianguoros Mongolian Autonomous County Hospital,Songyuan 131100,China)

机构地区：[1]吉林大学中日联谊医院心血管内科,长春130033 [2]吉林大学白求恩医学部,长春130033 [3]前郭尔罗斯蒙古族自治县医院心血管内科,松原131100

出　　处：《西南医科大学学报》2024年第4期355-363,共9页Journal of Southwest Medical University

基　　金：吉林省科学技术厅项目(20220402076GH)。

摘　　要：心外膜脂肪组织(epicardial adiposetissue,EAT)作为沉积在心脏周围的内脏脂肪库,已被证实与许多心血管疾病的发生发展密切相关,也因此受到了越来越多的关注。在病理情况下,它会通过旁分泌促炎及促纤维化脂肪因子、直接浸润、氧化应激等病理机制作用于临近心肌,诱导心肌重构,包括心房结构、电生理及功能重构。本文聚焦于EAT与心房重构的关系,通过探讨EAT的解剖特点、促进心房重构的病理生理机制、现有的影像学测量技术方法、临床评估的作用和意义及有效干预措施,还归纳了动物实验和临床研究的最新成果,对EAT和心房心肌病及心房重构的关联做一综述,以期为今后的相关机制研究和临床探索提供参考。Epicardial adipose tissue(EAT),a visceral fat depot deposited around the heart,has been proved to be closely asso-ciated with the development of many cardiovascular diseases,thus garnering growing attention.Under pathological conditions,it acts on the adjacent myocardium through pathological mechanisms such as paracrine pro-inflammatory and pro-fibrotic adipokines,direct infil-tration,and oxidative stress to induce myocardial remodeling,including atrial structural,electrophysiological,and functional remodel-ing.This article focused on the relationship between EAT and atrial remodeling,by exploring the anatomical features of EAT,the patho-physiological mechanisms that promote atrial remodeling,the available technical methods of imaging measurements,the roles and sig-nificance of clinical assessment,and effective interventions.Besides,the latest results of animal experiments and clinical studies were summarized to provide an overview of the association between EAT and atrial cardiomyopathy and atrial remodeling,with a view to pro-viding a reference for future related mechanism studies and clinical exploration.

关 键 词：心外膜脂肪组织 心房心肌病 心房重构 

分 类 号：R541.75[医药卫生—心血管疾病]