糖尿病患者低血糖事件负效用值测量:基于时间权衡法  

The Measurement of Disutility of Hypoglycemia on Health-related Quality of Life in Patients with Diabetes:Based on Time Trade-off Survey

作　　者：尹艺驰 史钊 李顺平 Yin Yichi;Shi Zhao;Li Shunping(Centre for Health Management and Policy Research,School of Public Health,Cheeloo College of andong University,NHC Key Laboratory of Health Economics and Policy Research(Shandong University),Center for ence Research,Shandong University,Jinan,250012,China;不详)

机构地区：[1]山东大学齐鲁医学院公共卫生学院卫生管理与政策研究中心·国家卫生健康委员会卫生经济与政策研究重点实验室(山东大学)·山东大学健康偏好研究中心,济南250012

出　　处：《中国卫生经济》2024年第6期64-67,共4页Chinese Health Economics

基　　金：国家自然科学基金面上项目(72374127)。

摘　　要：目的:测量不同低血糖事件对糖尿病患者健康相关生命质量的影响,为卫生技术评估提供参数支持.方法:数据来源于山东省济南市某三甲医院,用时间权衡法(TTO)测量健康效用值,根据公式计算负效用值,并分析不同低血糖事件组间差异.结果:低血糖事件效用值均值低于糖尿病无低血糖事件(基线状态)效用值均值;严重低血糖事件负效用值均值(0.108)高于不严重低血糖事件负效用值均值(0.008);夜间严重/不严重低血糖事件负效用值均值(0.118/0.008)高于日间严重/不严重低血糖事件负效用值均值(0.098/0.007).结论:糖尿病管理应加强对严重低血糖事件和夜间低血糖事件的关注.Objective:Evaluating the impact of various hypoglycemic events on the Health-Related Quality of Life(HRQoL)of diabetes patients to provide empirical data for health technology assessment.Methods:The data was collected from a tertiary hospital in Jinan,Shandong Province,China.Health utility was measured using the Time Trade-off(TTO)method,and disutility was calculated based on the formula.Subsequently,the intergroup differences among various hypoglycemic event groups were analyzed.Results:The hypoglycemic events'average utility was all lower than the average utility for diabetics without hypoglycemic events(baseline status).Severe hypoglycemic events(0.108)had higher disutility compared to non-severe hypoglycemic events(0.008).Furthermore,nocturnal severe/non-severe hypoglycemic events(0.118/0.008)exhibited higher average disutility than daytime severe/non-severe hypoglycemic events(0.098/0.007).Conclusion:Optimal diabetes management demands prioritizing the prevention of both severe hypoglycemic events and nocturnal hypoglycemic events.

关 键 词：糖尿病患者 低血糖事件 时间权衡法 负效用值 

分 类 号：R1-9[医药卫生—公共卫生与预防医学] R95