齿状回环路中苔藓细胞功能的研究进展  

Research progress on mossy cell function in the dentate gyrus circuit

作　　者：张丽 苏明钊 苏全平[2] ZHANG Li;SU Mingzhao;SU Quanping(Graduate School,Jinzhou Medical University,Jinzhou 121000,China)

机构地区：[1]锦州医科大学研究生学院,121000 [2]临沂市人民医院中心实验室

出　　处：《临床神经病学杂志》2024年第3期222-225,共4页Journal of Clinical Neurology

基　　金：山东省自然科学基金项目(ZR2023MH362);临沂市重点研发计划项目(2022YX0011);山东第二医科大学附属医院科技发展项目(2023FYM025)。

摘　　要：苔藓细胞(MC)是星形胶质细胞的一种,它在海马齿状回(DG)细胞中的比例相当大。然而,关于其结构、功能以及在神经系统疾病中的作用仍不清楚。在癫痫发作期间,MC局部回路输入的变化会改变环路的兴奋性-抑制性稳态平衡,从而导致疾病的变化。存活的MC可对海马网络产生净抑制作用,从而对癫痫发作起到保护作用。此外,MC中c-fos蛋白的表达增加可以加强对新奇事物的记忆,并通过减少焦虑来提高认知能力。本文综述了MC在DG环路中的作用以及其在疾病治疗中的价值。Mossy cells(MC)are a type of astrocyte that make up a large percentage of the cells in the hippocampal dentate gyrus(DG).However,its structure,function and role in neurological disorders remain largely unclear.Changes in local circuit inputs to MC during seizures alter the excitatory-inhibitory homeostatic balance of the loop,leading to changes in disease.The net inhibitory effect on the hippocampal network exerted by surviving MC,thus providing protection against seizures.Furthermore,increased expression of c-fos protein in MC enhances memory for novelty and also improves cognitive performance by reducing anxiety.This article reviews the role of MC in the dentate gyrus loop and its value in disease management.

关 键 词：齿状回 苔藓细胞 癫痫 焦虑 认知 

分 类 号：R363[医药卫生—病理学]