MR T_(1)-mapping成像在定量评估儿童肾功能不全中的应用  

Application of MR T_(1)-mapping imaging in the quantitative assessment of renal insufficiency in children

作　　者：顾东浩 胡俊[1] 尹传高 王凯旋 赵佳佳[1] GU Donghao;HU Jun;YIN Chuangao;WANG Kaixuan;ZHAO Jiajia(Department of Radiology,Children’s Hospital of Anhui Medical University,the Fifth Clinical Medical College of Anhui Medical University,Hefei 230051,China)

机构地区：[1]安徽医科大学附属省儿童医院影像科安徽医科大学第五临床医学院,安徽合肥230051

出　　处：《实用放射学杂志》2024年第6期944-947,1006,共5页Journal of Practical Radiology

摘　　要：目的探讨MR T_(1)-mapping成像技术为临床定量评估肾功能不全患儿肾脏功能状态提供附加指标的可能性。方法选取肾功能不全且行肾功能MRI检查患儿13例(肾功能不全组),同期纳入23例肾功能正常儿童作为对照组。比较2组肾皮质T_(1)值之间的差异,并分析肾功能不全组肾皮质T_(1)值与血肌酐(SCr)、胱抑素C(CysC)等生化指标的相关性。结果肾功能不全组与对照组肾皮质T_(1)值差异有统计学意义(P<0.01);肾功能不全组肾皮质T_(1)值与SCr、CysC相关性较高(r=0.75,P<0.01;r=0.68,P<0.01)。结论MR T_(1)-mapping技术能够无创监测肾功能不全患儿肾脏功能状态,对临床定量评价儿童肾功能具有提示价值。Objective To explore the possibility of MR T_(1)-mapping imaging technology to provide additional indicators for clinical quantitative evaluation of renal function in children with renal insufficiency.Methods A total of 13 children with renal insufficiency diagnosed and underwent renal function MRI examination were selected(renal insufficiency group),and 23 children with normal renal function were included as the control group.The difference of renal cortex T_(1)value between the control group and the renal insufficiency group was compared,and the correlation between renal cortex T_(1)value and biochemical indexes such as serum creatinine(SCr)and cystatin C(CysC)in the renal insufficiency group was analyzed.Results There was significant difference in T_(1)value of renal cortex between the renal insufficiency group and the control group(P<0.01).The correlation between T_(1)value of renal cortex and SCr and CysC in renal insufficiency group was higher(r=0.75,P<0.01;r=0.68,P<0.01).Conclusion MR T_(1)-mapping technology can non-invasively monitor the renal function status of children with renal insufficiency,and has a suggestive value for clinical quantitative evaluation of renal function in children.

关 键 词：儿童 肾功能不全 磁共振成像 T_(1)-mapping 

分 类 号：R726.9[医药卫生—儿科] R692[医药卫生—临床医学] R445.2