口服钆布醇在三维可变反转角快速自旋回波MR胰胆管成像中的应用  

Application of oral Gadovist in three-dimensional sampling perfection with application optimized contrasts using different flip angle evolutions MR cholangiopancreatography

作　　者：张子东 曹沛彩 赵洪全 陈玉飞 ZHANG Zidong;CAO Peicai;ZHAO Hongquan;CHEN Yufei(Department of Radiology,Yantai Yeda Hospital,Yantai,Shandong Province 264006,China)

机构地区：[1]烟台业达医院影像科,山东烟台264006

出　　处：《实用放射学杂志》2024年第6期998-1001,共4页Journal of Practical Radiology

摘　　要：目的研究口服钆布醇溶液提高三维可变反转角快速自旋回波磁共振胰胆管成像(3D-SPACE-MRCP)图像质量的合适浓度。方法体外实验:将0.05%、0.1%、0.15%、0.2%的钆布醇溶液及直饮水分别置入100 mL塑料容器中,进行3D-SPACEMRCP序列扫描,测量各组钆布醇溶液的信号强度(SI)。将钆布醇溶液浓度与SI进行Spearman相关性分析,各浓度钆布醇溶液的SI进行单因素方差分析。临床实验:将128例被试随机分成4组,分别口服0.05%、0.1%、0.15%、0.2%的钆布醇溶液300 mL并进行3D-SPACE-MRCP序列扫描,由2名医师评价图像质量并进行单因素方差分析。结果体外实验:钆布醇溶液浓度与SI呈极强负相关(r=-0.969,P<0.05),不同浓度钆布醇溶液的SI比较有显著性差异(P<0.05)。临床实验:26例1级图像有24例分布于0.1%钆布醇溶液组,口服不同浓度钆布醇溶液的3D-SPACE-MRCP图像比较差异有统计学意义(F=89.57,P<0.05),Tukey检验0.15%与0.2%钆布醇溶液组图像比较差异无统计学意义(P>0.05)。结论口服钆布醇溶液能明显提高3D-SPACEMRCP图像质量,0.1%是合适的稀释浓度。Objective To study the appropriate concentration of oral Gadovist solution for improving the image quality of three-dimensional sampling perfection with application optimized contrasts using different flip angle evolutions magnetic resonance cholangiopancreatography(3D-SPACE-MRCP).Methods In vitro experiments,0.05%,0.1%,0.15%and 0.2%Gadovist solution and direct drinking water were put into 100 mL plastic containers respectively for 3D-SPACE-MRCP scanning to measure the signal intensity(SI)of Gadovist solutions in each group.The concentration and the SI of Gadovist solution were analyzed with Spearman correlation,and one-way variance analysis was performed to compare the SI of different concentration Gadovist solutions.In clinical experiments,128 subjects were randomly divided into 4 groups,and then taken orally 300 mL of 0.05%,0.1%,0.15%and 0.2%Gadovist solutions respectively.The 3D-SPACE-MRCP scanning was performed,and the image quality was evaluated by two physicians and compared by one-way variance analysis.Results In vitro experiments,there was an extremely strong negative correlation between the concentration and the SI of Gadovist solution(r=-0.969,P<0.05),and there were significant differences in the SI among different concentrations of Gadovist solution(P<0.05).In clinical experiments,among the 26 cases with first-level images,24 cases were distributed in the 0.1%Gadovist solution group.There was a statistically significant difference in image quality of the 3D-SPACE-MRCP with different oral concentrations of Gadovist solution(F=89.57,P<0.05),however,there was no statistically significant difference between the 0.15%and the 0.2%Gadovist solution groups using the Tukey test(P>0.05).Conclusion Oral Gadovist solution can significantly improve the images quality of 3D-SPACE-MRCP,and 0.1%solution is the appropriate dilution concentration.

关 键 词：钆布醇 三维可变反转角快速自旋回波 磁共振胰胆管成像 图像质量 浓度 

分 类 号：R981.1[医药卫生—药品] R445.2[医药卫生—药学] R814.49