孤独症谱系障碍患者血维生素D水平和临床表征与嗅觉异常之间的关系  

The relationship between serum Vitamin D levels and clinical characterization in patients with Autism Spectrum Disorder and olfactory abnormalities

作　　者：张哲培 任鹏程 陈绵聪 李虹艾 赵婵娟[1] 向伟 ZHANG Zhepei;REN Pengcheng;CHEN Miancong;LI Hongai;ZHAO Chanjuan;XIANG Wei(International School of Public Health and One Health,Hainan Medical University,Haikou,Hainan 571199,China;School of Basic Medicine and Life Sciences,Hainan Medical University,Haikou,Hainan 571199,China;Hainan Women and Children's Medical Center,Haikou,Hainan 570312,China)

机构地区：[1]海南医学院公共卫生与全健康国际学院,海南海口571199 [2]海南医学院基础医学与生命科学学院,海南海口571199 [3]海南省妇女儿童医学中心,海南海口570312

出　　处：《国际检验医学杂志》2024年第S01期74-78,共5页International Journal of Laboratory Medicine

基　　金：海南医学院研究生创新课题(HYYS2022B01)。

摘　　要：目的探讨伴有嗅觉异常的孤独症谱系障碍(ASD)患者血25(OH)D水平与临床表征之间的关系,为ASD的病因及临床诊断和治疗提供科学的理论依据。方法采用病理对照的研究方法,收集2022年8月至2023年8月位于海南省海口市海旅大健康儿童康复中心就诊的ASD儿童115例。根据SPSRC量表将ASD患儿分为嗅觉异常组和嗅觉正常组,将32例嗅觉异常的ASD患儿作为病例组,1∶1年龄、性别匹配的嗅觉正常的ASD儿童作为对照组,比较两组25(OH)D水平及临床表征数据的差异。使用液相色谱串联质谱法(LC-MS/MS)对血清25(OH)D水平进行检测。使用简版感觉处理能力剖析量表(SSP)、刻板重复行为量表修订版(RBS-R)、社交反应量表第二版(SRS-2)、孤独症谱系问卷量表(AQ)对两组儿童的临床表征进行评估。结果嗅觉异常组血25(OH)D水平、SSP评分、SRS-2评分均低于对照组,差异有统计学意义(t=4.460,P<0.001)。Logistic回归分析显示25(OH)D是否<25 ng/mL(β=1.433,OR=4.192)、SSP评分是否<115(β=1.838,OR=6.286)为疾病独立的危险因素(均P<0.05)。结论伴有嗅觉异常的ASD患儿血25(OH)D含量较低,且与嗅觉和部分临床表型存在相关性,但具体机制有待进一步探讨。Objective To investigate the relationship between serum Vitamin D(25(OH)D)levels and clinical characteristics in patients with Autism Spectrum Disorder(ASD)accompanied by olfactory anomalies,providing a scientific theoretical foundation for the etiology,clinical diagnosis,and treatment of ASD.Methods A case-control study design was adopted,involving 115 children diagnosed with ASD at the Haikou City Hai lv Da Jian Kang Children's Rehabilitation Center in Hainan Province from August 2022 to August 2023.According to the Smell Perception and Rating Scale for Children(SPSRC),the children with ASD were divided into an olfactory anomaly group and an olfactory normative group.The case group consisted of 32 children with olfactory anomalies,while the control group comprised an age and gender-matched cohort of 32 children with normal olfactory function.The differences in 25(OH)D levels and clinical characteristics between the two groups were compared.Serum 25(OH)D levels were measured using liquid chromatography-tandem mass spectrometry(LC-MS/MS).Clinical characteristics of both groups were assessed using the Short Sensory Profile(SSP),the Repetitive Behavior Scale-Revised(RBS-R),the Social Responsiveness Scale-Second Edition(SRS-2),and the Autism-Spectrum Quotient(AQ).Results The total 25(OH)D levels,SSP scores,and SRS-2 scores were significantly lower in the olfactory anomaly group compared to the control group,and the differences were statistically significant(t=4.460,P<0.001).Logistic regression analysis indicated that total 25(OH)D levels<25ng/mL(β=1.433,OR=4.192)and SSP scores<115(β=1.838,OR=6.286)were in-dependent risk factors for the disease(P<0.05).Conclusion Children with ASD and olfactory anomalies were found to have lower serum 25(OH)D levels,and these levels were correlated with olfactory and certain clinical phenotypes.However,the specific mechanisms warrant further exploration.

关 键 词：孤独症谱系障碍 维生素D 嗅觉 病例对照研究 儿童 

分 类 号：R446[医药卫生—诊断学]