血sIL-2R、CRP、WBC与围术期输血患者感染的相关性研究  

Exploring the correlation between sIL-2R,CRP,WBC and infection in perioperative blood transfusion patient

作　　者：陈雪梅 邓文斌 田小军 CHEN Xuemei;DENG Wenbin;TIAN Xiaojun(Blood Transfusion Department,Mianyang Hospital Affiliated to the School of Medicine of University of Electronic Science and Technology of China·Mianyang Central Hospital,Mianyang,Sichuan 621000,China;Laboratory Department,Mianyang Hospital Affiliated to the School of Medicine of University of Electronic Science and Technology of China·Mianyang Central Hospital,Mianyang,Sichuan 621000,China)

机构地区：[1]电子科技大学医学院附属绵阳医院·绵阳市中心医院输血科,四川绵阳621000 [2]电子科技大学医学院附属绵阳医院·绵阳市中心医院检验科,四川绵阳621000

出　　处：《国际检验医学杂志》2024年第S01期160-163,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨血可溶性白介素-2受体(sIL-2R)、白细胞计数(WBC)、C反应蛋白(CRP)与围术期输血患者感染的相关性。方法选取2020年8月至2023年2月该院围术期输血后感染者37例设为研究组,根据1∶1原则选取同期在该院接受输血但无感染的37例为对照组。抽取所有受检者空腹静脉血,经酶联免疫吸附试验测定sIL-2R、CRP表达,用血细胞分析仪测定WBC,并对研究组实施抗感染治疗。统计研究组与对照组不同感染情况(感染位置、感染程度)及不同感染控制情况者血sIL-2R、WBC、CRP表达,分析血sIL-2R、WBC、CRP表达与感染情况的相关性。结果研究组血sIL-2R、WBC、CRP高于对照组,差异有统计学意义(P<0.05)。深部感染者、重度感染者血sIL-2R、WBC、CRP高于浅表感染者、轻中度感染者(P<0.05)。经Spearman检验证实,血sIL-2R、WBC、CRP与感染位置、感染程度呈显著正相关关系(P<0.05)。研究组感染控制31例、感染未控制6例,感染控制者血sIL-2R、WBC、CRP低于未控制者,差异有统计学意义(P<0.05)。结论围术期输血后感染患者sIL-2R、WBC、CRP异常增高,增高幅度与感染位置、感染程度存在正相关关系,且通过监测上述指标还可评估感染控制情况。Objective To explore the correlation between soluble interleukin-2 receptor(sIL-2R),white blood cell count(WBC),C-reactive protein(CRP)and infection in perioperative blood transfusion patients.Methods Thirty seven postoperative infected individuals in Mianyang Hospital Affiliated to the School of Medicine of University of Electronic Science and Technology of China·Mianyang Central Hospital hospital from August 2020 to February 2023 were selected as the study group,and 37 non infected individuals who received blood transfusion in our hospital during the same period were selected as the control group according to the 1:1 principle.Extract fasting venous blood from all subjects,measure the expression of sIL-2R and CRP using enzyme-linked immunosorbent assay,measure WBC using a blood cell analyzer,and implement anti infection treatment for the study group.Analyze the correlation between the expression of sIL-2R,WBC,and CRP in the blood of patients with different infection conditions(infection location,degree)and infection control between the research group and the control group,and the infection status.Results The levels of sIL-2R,WBC,and CRP in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of sIL-2R,WBC,and CRP in the blood of patients with deep infection and severe infection were higher than those of patients with superficial infection and mild to moderate infection(P<0.05).Spearman's test confirmed a significant positive correlation(P<0.05)between blood sIL-2R,WBC,CRP and infection location and severity.There were 31 cases of infection control and 6 cases of infection uncontrolled in the research group.The levels of sIL-2R,WBC,and CRP in the blood of the infection controlled individuals were lower than those of the uncontrolled individuals,and the differences were statistically significant(P<0.05).Conclusion The sIL-2R,WBC,and CRP levels in patients with postoperative infection after blood transfusion are abnormally increased,and

关 键 词：围术期输血 感染 可溶性白细胞介素-2受体 C反应蛋白 白细胞计数 

分 类 号：R446.6[医药卫生—诊断学] R457[医药卫生—临床医学]