Bioinspired 4D Printing Shape-Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment  

作　　者：Jiaqi Liu Guiwei Li He Liu Jincheng Wang Hui Wang Xue Gao Qingping Liu Chenyu Wang 

机构地区：[1]Department of Plastic and Reconstructive Surgery,The First Hospital of Jilin University,Changchun,130021,China [2]Department of Orthopaedics,The Second Hospital of Jilin University,Changchun,130041,China [3]Key Laboratory of Bionic Engineering(Ministry of Education),Jilin University,Changchun,130022,China

出　　处：《Journal of Bionic Engineering》2024年第3期1397-1411,共15页仿生工程学报（英文版）

基　　金：financially supported by the talent reserve program of the first hospital of Jilin University(Grant Nos.JDYY-TRP-2024002);the National Natural Science Foundation of China(Grant Nos.82372391,82001971,82102358 and 82202698);Scientific Development Program of Jilin Province(Grant Nos.20200403088SF,20220204117YY,YDZJ202201ZYTS086,20200404202YY and 20200802008GH);Program of Jilin Provincial Health Department(Grant No.2020SC2T064 and 2020SC2T065);Project of"Medical+X"Interdisciplinary Innovation Team of Norman Bethune Health Science Center of Jilin University(Grant No.2022JBGS06);China Postdoctoral Science Foundation(Grant No.2021M701384);Bethune Plan of Jilin University(Grant No.2022B27,2022B03).

摘　　要：The disparity between the postoperative outcomes of rhinoplasty and the expected results frequently necessitates secondary or multiple surgeries as a compensatory measure,greatly diminishing patient satisfaction.However,there is renewed optimism for addressing these challenges through the innovative realm of Four-Dimensional(4D)printing.This groundbreaking technology enables three-dimensional objects with shape-memory properties to undergo predictable transformations under specific external stimuli.Consequently,implants crafted using 4D printing offer significant potential for dynamic adjustments.Inspired by worms in our research,we harnessed 4D printing to fabricate a Shape-Memory Polyurethane(SMPU)for use as a nasal augmentation prosthesis.The choice of SMPU was guided by its Glass Transition Temperature(Tg),which falls within the acceptable temperature range for the human body.This attribute allowed for temperature-responsive intraoperative self-deformation and postoperative remodeling.Our chosen animal model for experimentation was rabbits.Taking into account the anatomical structure of the rabbit nose,we designed and produced nasal augmentation prostheses with superior biocompatibility.These prostheses were then surgically implanted in a minimally invasive manner into the rabbit noses.Remarkably,they exhibited successful temperature-controlled in-surgery self-deformation according to the predetermined shape and non-invasive remodeling within a mere 9 days post-surgery.Subsequent histological evaluations confirmed the practical viability of these prostheses in a living organism.Our research findings posit that worm-inspired 4D-printed SMPU nasal prostheses hold significant promise for achieving dynamic aesthetic adjustments.

关 键 词：4D printing Shape memory polyurethane RHINOPLASTY Self-deformation Dynamic aesthetic adjustment 

分 类 号：R318[医药卫生—生物医学工程] TP391.73[医药卫生—基础医学]