含氧杂环化合物合成研究  

Synthesis of Oxygen-containing Heterocyclic Compounds

作　　者：纪凤婷 胡祎波 彭林 Ji Fengting;Hu Yibo;Peng Lin(Food and Chemical Engineering in the Shaoyang University,Shaoyang 422000,China)

机构地区：[1]邵阳学院食品与化学工程学院,湖南邵阳422000

出　　处：《广东化工》2024年第11期18-19,74,共3页Guangdong Chemical Industry

基　　金：邵阳学院研究生科研创新项目(CX2022SY068);湖南省自然科学基金资助项目(2023JJ50038)。

摘　　要：含氧杂环化合物广泛存在于天然产物中,在医药、食品等领域有广泛研究及应用,是天然活性物质的重要组成部分。本研究利用磷酸催化剂作用于α,β-不饱和酮类化合物,催化关环,利用迈克尔加成机理得到十三元含氧杂环化合物。本文在以6-庚炔-1-醇为起始原料经过烷基化、戴斯马丁氧化、witting反应、迈克尔加成等一系列的条件温和、操作简单的反应成功合成了含氧杂环化合物。为含氧杂环化合物的人工合成提供了一定的参考。Oxygen-containing heterocyclic compounds are widely existed in natural products,which have been widely studied and applied in the fields of medicine,food and so on,and are important components of natural active substances.In this study,we used phosphoric acid catalyst to act onα,β-unsaturated ketones to catalyse the ring closure,and obtained thirteen-membered oxygen-containing heterocyclic compounds by Michael addition mechanism.In this paper,the oxygenated heterocyclic compounds were successfully synthesised after a series of mild and simple reactions,including alkylation,Desmartin oxidation,witting reaction and Michael addition,using 6-heptyn-1-ol as the starting material.It provides a certain reference for the synthetic synthesis of oxygen-containing heterocyclic compounds.

关 键 词：磷酸催化 含氧杂环化合物 迈克尔加成 

分 类 号：TQ[化学工程]