溶酶体pH稳态对细胞自噬体和自噬流的影响研究  

Effect of Lysosomal pH Homeostasis on Cellular Autophagosomes and Autophagic Flow

作　　者：成怡沁 彭保卫 Cheng Yiqin;Peng Baowei(Dali University,Dali 671000,China)

机构地区：[1]大理大学,云南大理671000

出　　处：《广东化工》2024年第12期47-49,共3页Guangdong Chemical Industry

摘　　要：正常pH条件下,溶酶体可有效消化和降解受损的细胞器和生物大分子,并在细胞消化自噬过程中发挥着重要的作用;溶酶体pH值异常会导致溶酶体中的水解酶失活或受损,这可能会影响溶酶体与自噬体的融合,导致自噬体堆积和自噬通量受阻。因此,溶酶体pH稳态对于了解和研究自噬过程至关重要。Under normal pH conditions,lysosomes can effectively digest and degrade damaged organelles and biomolecules,and play an important role in cellular digestive autophagy;abnormal lysosomal pH leads to inactivation or impairment of hydrolytic enzymes in lysosomes,which may affect the fusion of lysosomes with autophago-somes,leading to accumulation of autophagosomes and impaired autophagic flux.Therefore,lysosomal pH homeostasis is essential for understanding and studying the autophagy.

关 键 词：溶酶体 PH 自噬体 自噬溶酶体 自噬流 

分 类 号：R94[医药卫生—药剂学]