CT肺动脉血管造影联合血清Apelin-13、IL-38在急性肺栓塞诊断中的临床价值  

Clinical Value of CT Pulmonary Angiography Combined with Serum Apelin-13 and IL-38 in the Diagnosis of Acute Pulmonary Embolism

作　　者：马玉萍[1] 栾丽[1] 陶思冥 MA Yu-ping;LUAN Li;TAO Si-ming(Departments of Medical Imaging,The Affiliated Hospital of Xinjiang University of TraditionalChinese Medicine,Urumqi 830000,Xinjiang Uygur Autonomous Region,China;The Third Department of Pulmonary Disease,The Affiliated Hospital of Xinjiang University ofTraditional Chinese Medicine,Urumqi 830000,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆医科大学附属中医医院医学影像科,新疆乌鲁木齐830000 [2]新疆医科大学附属中医医院肺病三科,新疆乌鲁木齐830000

出　　处：《中国CT和MRI杂志》2024年第7期60-62,共3页Chinese Journal of CT and MRI

基　　金：新疆维吾尔自治区自然科学基金资助项目(2019D01C177);新疆医科大学附属中医医院院级课题(ZYY202005)。

摘　　要：目的探究CT肺动脉血管造影(CTPA)联合血清Apelin-13、白细胞介素-38(IL-38)在急性肺栓塞(APE)诊断中的临床价值。方法选取2021年5月-2023年5月本院收治的116例疑似APE患者,患者均行CTPA,根据其检测结果分为APE组和非APE组;酶联免疫吸附法检测Apelin-13、IL-38水平;APE的影响因素采用多因素Logistic回归分析;绘制ROC曲线分析血清Apelin-13、IL-38对APE的诊断价值。结果116例患者经过CTPA诊断出APE 49例(42.24%),主要包括23例中心型,82例偏心型,15例附壁血栓型,19例完全堵塞型。APE组血清Apelin-13、IL-38水平显著高于非APE组(P<0.05)。多因素Logistic回归分析得知Apelin-13、IL-38为影响APE的危险因素(P<0.05)。根据ROC曲线得知,血清Apelin-13诊断APE的AUC为0.859,血清IL-38诊断APE的AUC为0.864,二者联合诊断APE的AUC为0.952,二者联合优于各自单独诊断(Z_(联合vs Apelin-13)=2.681、Z_(联合vs IL-38)=2.739,P均<0.05)。结论Apelin-13、IL-38在APE患者血清中明显升高,CTPA可显示APE的部位和类型,CTPA联合血清Apelin-13、IL-38可提高APE的诊断价值。Objective To explore the clinical value of CT pulmonary angiography(CTPA)combined with serum Apelin-13 and interleukin-38(IL-38)in the diagnosis of acute pulmonary embolism(APE).Methods From May 2021 to May 2023,116 suspected APE patients admitted to our hospital were selected,all of whom underwent CTPA.According to their test results,they were grouped into APE group and non APE group;enzyme linked immunosorbent assay(ELISA)was applied to detect the levels of Apelin-13 and IL-38;the influencing factors of APE were analyzed using multiple Logistic regression analysis;ROC curve was plotted to analyze the diagnostic value of serum Apelin-13 and IL-38 for APE.Results Among 116 patients,49 cases(42.24%)were diagnosed with APE through CTPA,mainly including 23 cases of central heart type,82 cases of eccentric heart type,15 cases of wall thrombus type,and 19 cases of complete occlusion type.The serum levels of Apelin-13 and IL-38 in the APE group were obviously higher than those in the non APE group(P<0.05).Multivariate Logistic regression analysis revealed that Apelin-13 and IL-38 were risk factors affecting APE(P<0.05).According to the ROC curve,the AUC for diagnosing APE with serum Apelin-13 was 0.859,and the AUC for diagnosing APE with serum IL-38 was 0.864,the AUC for diagnosing APE with the combination of the two was 0.952,and the combination of the two was better than their respective individual diagnoses(Z_(combination vs Apelin-13)=2.681,Z_(combination vs IL-38)=2.739,P<0.05).Conclusion Apelin-13 and IL-38 are obviously elevated in the serum of APE patients,and CTPA can display the location and type of APE.The combination of CTPA and serum Apelin-13 and IL-38 can improve the diagnostic value for APE.

关 键 词：CT肺动脉血管造影 APELIN-13 白细胞介素-38 急性肺栓塞 诊断 

分 类 号：R445.3[医药卫生—影像医学与核医学]