健康体检人群血尿酸与气流阻塞的相关性  

Association between serum uric acid and airflow obstruction based on the health-checkup population

作　　者：周庆欣 杨晴晴 石舒原 李沛 孙凤[1] ZHOU Qingxin;YANG Qingqing;SHI Shuyuan;LI Pei;SUN Feng(Department of Epidemiology and Biostatistics,Peking University School of Public Health,Beijing 100191,China)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,北京100191

出　　处：《北京大学学报（医学版）》2024年第4期693-699,共7页Journal of Peking University:Health Sciences

摘　　要：目的:探讨中国台湾健康体检人群中血尿酸水平与肺功能指标和气流阻塞之间的相关性。方法:利用中国台湾美兆健康资源中心的体检资料,选取于1996—2016年间进行体检的40岁以上人群进行横断面分析,按照性别分别进行血尿酸水平与肺功能指标的相关性分析,以及血尿酸水平对气流阻塞影响的Logistic回归分析。结果:共纳入35465人,平均年龄(45.70±7.30)岁,男性16411人,女性19054人,其中,男性的血尿酸水平高于女性,存在气流阻塞的人群血尿酸水平高于无气流阻塞的人群。女性血尿酸水平与肺功能指标[第一秒用力呼气容积(forced expiratory volume in one second,FEV1)、用力肺活量(force vital capacity,FVC)]之间呈负相关(P<0.05),男性血尿酸水平与肺功能指标FEV1、FVC之间则无显著相关性(P>0.05)。在调整年龄、教育程度、吸烟、饮酒、工作强度、体重指数、是否咳嗽、高血压病史、糖尿病病史等指标,以及白细胞、白蛋白等生化指标后,随着血尿酸浓度的升高,女性更易存在气流阻塞(OR=1.12,95%CI:1.02~1.22,P<0.05)。按照是否患高尿酸血症进行分组,结果显示与血尿酸正常组相比,女性中高尿酸血症组更易存在气流阻塞(OR=1.36,95%CI:1.06~1.75,P<0.05),而男性中血尿酸浓度与气流阻塞患病之间无显著相关性(OR=1.04,95%CI:0.96~1.13,P>0.05),是否患高尿酸血症与气流阻塞的存在无显著相关性(OR=1.12,95%CI:0.89~1.39,P>0.05)。结论:女性健康体检人群中,血尿酸水平与肺功能指标FEV1、FVC之间存在负相关,高尿酸血症与气流阻塞的存在有相关性,在男性中则不明显。未来仍需要前瞻性研究来进一步验证高血尿酸水平是否与气流阻塞的发生相关联。Objective:To investigate the association between serum uric acid,pulmonary function and airflow obstruction in Chinese Taiwan healthy subjects.Methods:All the cross-sectional analysis was performed in the population over 40 years old using the physical examination data of Chinese Taiwan MJ Health Resource Center between 1996 and 2016 stratification by gender.The correlation analyses between serum uric acid were done and multivariate Logistic regression analysis was used to explore the effect of serum uric acid on airflow obstruction.Results:A total of 35465 people were included in the study,including 16411 men and 19054 women.Among them,the serum uric acid concentration of men was higher than that of women,and the serum uric acid concentration of the people with airflow obstruction was higher than that of the people without airflow obstruction.There was a negative correlation between serum uric acid level and the forced expiratory volume in one second(FEV1)and the force vital capacity(FVC)in women(P<0.05),but in men the correlation didn’t exist(P>0.05).After adjusting for age,education,smoking status,drinking status,work strength,body mass index,history of cough,history of hypertension,history of diabetes,history of dyslipidemia,white blood cells and blood albumin,the airflow obstruction in women was more likely to exist with the serum uric acid elevated(OR=1.12,95%CI:1.02-1.22,P<0.05).The results showed that women with hyperuricemia were more likely to have airflow obstruction than those without hyperuricemia(OR=1.36,95%CI:1.06-1.75,P<0.05).There was no correlation between serum uric acid concentration and airflow obstruction in men(OR=1.04,95%CI:0.96-1.13,P>0.05),also the hyperuricemia and airflow obstruction(OR=1.12,95%CI:0.89-1.39,P>0.05).Conclusion:There is a negative correlation between serum uric acid and FEV1 and FVC in relatively healthy women,and there is an association between elevated serum uric acid and airflow obstruction in women,but not in men.Further prospective studies are needed to explore wh

关 键 词：尿酸 呼吸功能试验 慢性阻塞性肺疾病 横断面研究 

分 类 号：R181.3[医药卫生—流行病学]