细胞焦亡在心肌缺血再灌注损伤中的作用  

The Role of Pyroptosis in Myocardial Ischemia Reperfusion Injury

作　　者：焦亚琼 李育林 胡伯昂 钟明[1] 韩露[1,2] 宋铭 JIAO Yaqiong;LI Yulin;HU Bo’ang;ZHONG Ming;HAN Lu;SONG Ming(National Key Laboratory for Innovation and Transformation of Luobing Theory,The Key Laboratory of Cardiovascular Remodeling and Function Research,Chinese Ministry of Education,Chinese National Health Commission and Chinese Academy of Medical Sciences,Department of Cardiology,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China;Department of General Practice,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China;Department of Cardiology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250001,Shandong,China)

机构地区：[1]络病理论创新转化全国重点实验室,山东大学心血管重构与功能研究教育部,国家卫健委及中国医学科学院重点实验室,心血管转换医学省部共建国家重点实验室,山东大学齐鲁医院心血管内科,山东济南250012 [2]山东大学齐鲁医院全科医学科,山东济南250012 [3]山东第一医科大学附属省立医院心内科,山东济南250001

出　　处：《心血管病学进展》2024年第6期539-542,561,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(82070392)。

摘　　要：细胞焦亡是一种新型促炎性细胞程序性死亡方式,其由NOD样受体热蛋白结构域相关蛋白3炎症小体活化启动,gasdermin D蛋白活性N端破坏细胞膜完整性,导致细胞死亡,随后引发炎症级联反应加重组织损伤。有研究表明,细胞焦亡可能参与心肌缺血再灌注损伤(MIRI)的发生发展。MIRI是限制急性心肌梗死临床疗效的重要原因之一。针对细胞焦亡的药物在MIRI疾病模型中能够挽救细胞焦亡所致心肌损伤。现就细胞焦亡在MIRI中的作用做一综述,并在此基础上探讨可能的治疗靶点。Pyroptosis is a novel pro-inflammatory programmed cell death modality,which is initiated by NOD-like receptor thermal protein domain associated protein 3 inflammasome activation,and the active N-terminus of gasdermin D destroys the integrity of the cell membrane,leading to cell death,and then triggering an inflammatory cascade to aggravate tissue damage.Studies have shown that pyroptosis may be involved in the development of myocardial ischemia reperfusion injury(MIRI).MIRI is one of the important reasons limiting the clinical efficacy of acute myocardial infarction.Drug targeting pyroptosis can save myocardial injury caused by pyroptosis in a disease model of MIRI.This article reviews the role of pyroptosis in myocardial ischemia reperfusion injury,and discusses possible therapeutic targets on this basis.

关 键 词：缺血再灌注损伤 细胞焦亡 氧化应激 炎症反应 药物治疗 

分 类 号：R54[医药卫生—心血管疾病]