模式识别受体在糖尿病心肌病中的研究进展  

Pattern Recognition Receptors in Diabetic Cardiomyopathy

作　　者：董泽耀 庄小密 鲁静[1] DONG Zeyao;ZHUANG Xiaomi;LU Jing(The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2024年第6期548-551,共4页Advances in Cardiovascular Diseases

基　　金：黑龙江省博士后科研启动资助金(LBH-Q20119)。

摘　　要：糖尿病心肌病(DCM)是糖尿病患者死亡的主要原因,但确切调控机制仍不清楚。近年研究发现,固有免疫应答是DCM发展过程的中心环节。模式识别受体是执行固有免疫功能的重要分子,主要包括Toll样受体、NOD样受体、视黄酸诱导基因Ⅰ样受体、C型凝集素受体、黑色素瘤缺乏因子2样受体、清道夫受体和环状GMP-AMP合成酶。现就上述几种模式识别受体在DCM中作用的研究进展进行综述,以期为DCM的临床治疗提供新思路和新靶点。Diabetic cardiomyopathy(DCM)is a leading cause of death among patients with diabetes,yet the precise regulatory mechanisms remain unclear.Recent studies have discovered that the innate immune response plays a central role in the progression of DCM.Pattern recognition receptors are critical molecules that execute the functions of the innate immune system,including Toll-like receptor,NOD-like receptor,retinoic acid-inducible gene-Ⅰ-like receptor,C-type lectin receptor,absent in melanoma 2-like receptor,scavenger receptor,and cyclic GMP-AMP synthase.This review summarizes the research progress on the role of these pattern recognition receptors in DCM,aiming to provide new insights and targets for the clinical treatment of DCM.

关 键 词：糖尿病心肌病 模式识别受体 固有免疫应答 炎症反应 

分 类 号：R587.2[医药卫生—内分泌] R542.2[医药卫生—内科学]