经鼻高流量湿化氧疗对急性左心衰竭急诊急救患者血气指标和心功能及脑钠肽水平的影响  

Effects of humidified high flow nasal cannula oxygen therapy on blood gas indicators and cardiac function and brain natriuretic peptide levels in emergency patients with acute left heart failure

作　　者：郑亮亮 路通 蔡向阳 ZHENG Liangliang;LU Tong;CAI Xiangyang(Department of Emergency,Liaocheng Maternal and Child Health Hospital,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市妇幼保健院急诊科,山东聊城252000

出　　处：《当代医学》2024年第11期10-14,共5页Contemporary Medicine

摘　　要：目的探究经鼻高流量湿化氧疗(HFNC)治疗急性左心衰竭(ALVF)急诊急救患者的效果。方法选取2020年1月至2022年6月聊城市妇幼保健院收治的90例ALVF患者作为研究对象,采用随机数字表法分为对照组与研究组,每组45例。对照组采用常规氧疗,研究组采用HFNC治疗。比较两组血气分析指标[动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))及氧合指数(PaO_(2)/FiO_(2))]、生命体征[呼吸频率(RR)、心率(HR)及平均动脉压(MAP)]、心功能[左心室射血分数(LVEF)、每搏输出量(SV)]、脑钠肽(BNP)、舒适状况[舒适状况量表(GCQ)评分]、健康状况[健康状况调查简表(SF-36)评分]。结果治疗24 h后,研究组PaO_(2)、SaO_(2)及PaO_(2)/FiO_(2)均高于对照组,差异有统计学意义(P<0.05)。治疗24 h后,研究组RR、HR均慢于对照组,MAP低于对照组,差异有统计学意义(P<0.05)。治疗24 h后,研究组LVEF高于对照组,SV大于对照组,差异有统计学意义(P<0.05)。治疗6、12、24 h后,研究组BNP水平均低于对照组,差异有统计学意义(P<0.05)。治疗24 h后,研究组生理、心理、环境、社会文化评分均高于对照组,差异有统计学意义(P<0.05)。治疗24 h后,研究组生理功能、生理职能、精神健康、生命活力、躯体疼痛、社会功能、情感职能、总体健康评分均高于对照组,差异有统计学意义(P<0.05)。结论HFNC可有效改善ALVF患者氧合指数与心功能,降低BNP水平,提高其身心舒适度。Objective To investigate the effects of humidified high flow nasal cannula oxygen therapy(HFNC)in emergency patients with acute left heart failure(ALVF).Methods A total of 90 ALVF patients admitted to Liaocheng Maternal and Child Health Hospital from January 2020 to June 2022 were selected as the study subjects,and they were divided into the control group and the study group by random number table method,with 45 cases in each group.The control group was treated with conventional oxygen therapy,and the study group was treated with HFNC.The blood gas analysis indexes(partial pressure of arterial oxygen[PaO_(2)],arterial oxygen saturation[SaO_(2)]and oxygenation index[PaO_(2)/FiO_(2)]),vital signs(respiratory rate[RR],heart rate[HR]and mean arterial pressure[MAP]),heart function(left ventricular ejection fraction[LVEF],stroke volume[SV])and brain natriuretic peptide(BNP),comfort status(general comfort questionnaire[GCQ]scores)and health status(the MOS item short from health survey[SF-36]scores)were compared between the two groups.Results After 24 h of treatment,PaO_(2),SaO_(2) and PaO_(2)/FiO_(2) in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After 24 h of treatment,RR,HR in the study group were slower than those in the control group,MAP was lower than that in the control group,and the differences were statistically significant(P<0.05).After treatment,LVEF in the study group was higher than that in the control group,and SV was larger than that in the control group,and the differences were statistically significant(P<0.05).After 6,12,24 h treatment,the BNP level in the study group were lower than that in the control group,and the differences were statistically significant(P<0.05).After 24 h of treatment,the scores of physiological,psychological,environmental and sociocultural in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).After 24 h of treatment,the scores of physiologi

关 键 词：急性左心衰竭 经鼻高流量湿化氧疗 氧合指数 脑钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]