沙库巴曲缬沙坦钠片对急性心肌梗死患者心室重构及肾小球滤过率的影响  

The effect of sacubitril/valsartan on ventricular remodeling and glomerular filtration rate in patients with acute myocardial infarction

作　　者：俞芽法 龚资庆 李金程[1] 石泉[1] YU Yafa;GONG Ziqing;LI Jincheng;SHI Quan(Department of Cardiovascular Medicine,Fuzhou First People's Hospital,Fuzhou,Jiangxi,344000,China)

机构地区：[1]抚州市第一人民医院心血管内科,江西抚州344000

出　　处：《当代医学》2024年第11期34-38,共5页Contemporary Medicine

基　　金：抚州市社会发展指导性科技计划项目[抚科社字(2022)9号]。

摘　　要：目的探究沙库巴曲缬沙坦钠片(SV)对急性心肌梗死(AMI)患者心室重构及肾小球滤过率(GFR)的影响。方法选取2022年4月至2023年10月抚州市第一人民医院收治的120例行经皮冠状动脉介入术(PCI)的AMI患者作为研究对象,根据所用药物不同分为对照组与研究组,每组60例。对照组给予传统药物治疗,研究组给予SV治疗。比较两组血压、心率、心功能、肾功能、心衰程度、临床疗效及不良反应发生情况。结果治疗后,两组心率及研究组收缩压、舒张压均低于治疗前,且研究组收缩压、舒张压、心率均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组左心室射血分数(LVEF)均高于治疗前,左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)均小于治疗前,且研究组LVEF高于对照组,LVESV、LVEDV均小于对照组,差异有统计学意义(P<0.05)。治疗后,两组肾小球滤过率(GFR)、血清尿素氮(BUN)、肌酐(Cr)水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组N末端脑钠肽前体(NT-proBNP)水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。研究组治疗期间不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论SV治疗行PCI的AMI患者疗效显著,可有效改善患者心功能,延缓心力衰竭进展,抑制心室重构,保护肾功能,值得临床推广应用。Objective To investigate the effects of sacubitril/valsartan(SV)on ventricular remodeling and glomerular filtration rate(GFR)in patients with acute myocardial infarction(AMI).Methods 120 AMI patients who underwent percutaneous coronary intervention(PCI)and were admitted to the First People's Hospital of Fuzhou City from April 2022 to October 2023 were selected as the study subjects,and they were divided into the control group and the study group based on the different drugs used,with 60 cases in each group.The control group was treated with traditional drugs,while the study group was treated with SV.The blood pressure,heart rate,heart function,renal function,degree of heart failure,clinical efficacy,and occurrence of adverse reactions were compared between two groups.Results After treatment,the heart rate of the two groups and the systolic blood pressure and diastolic blood pressure in the study group were lower than those before treatment,and the systolic blood pressure,diastolic blood pressure,and heart rates in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)of the two groups was higher than before treatment,and the left ventricular end systolic volume(LVESV)and left ventricular end diastolic volume(LVEDV)were smaller than before treatment,the LVEF in the study group was higher than that in the control group,while LVESV and LVEDV were smaller than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the glomerular filtration rate(GFR),serum urea nitrogen(BUN),and creatinine(Cr)levels of the two groups were lower than before treatment,and the study group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the level of N-terminal brain natriuretic peptide precursor(NT-proBNP)of the two groups was lower than before treatment,and the study group was lower than that in the control gro

关 键 词：沙库巴曲缬沙坦钠片 急性心肌梗死 心室重构 肾小球滤过率 

分 类 号：R542.22[医药卫生—心血管疾病]