19~<30岁男性官兵血清尿酸对肾脏功能的影响及因素分析  

Analysis effect and factors of serum uric acid on renal function in male officers and soldiers aged 19-<30 years old

作　　者：陈润瑶 伍豪 张丽婷[1] 许正锯[1] CHEN Runyao;WU Hao;ZHANG Liting;XU Zhengju(The 910th Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army,Quanzhou,Fujian 362000,China)

机构地区：[1]中国人民解放军联勤保障部队第九一○医院,福建泉州362000

出　　处：《现代医药卫生》2024年第14期2362-2366,共5页Journal of Modern Medicine & Health

基　　金：福建省泉州市2021年医疗卫生领域指导性科技计划项目(2021N164S)。

摘　　要：目的探索19~<30岁男性官兵血尿酸(SUA)对肾小球滤过率(eGFR)的影响及相关因素分析,为保障官兵健康提供理论依据。方法收集2022年该院体检的部队男性官兵年龄、体重指数和生化指标,并进行统计分析。结果相对于其他年龄段,19~<30岁官兵SUA浓度和高尿酸血症检出率最高(P≤0.001);此年龄段官兵SUA与eGFR呈负相关(r=-0.24,P<0.001);ROC分析显示,SUA浓度对eGFR受损有预测价值(AUC=0.661),SUA>503μmol/L时eGFR损害率显著增加;回归分析显示,SUA[校正比值比(OR)=1.003,95%可信区间(95%CI)1.001~1.006,P=0.018]和低密度脂蛋白胆固醇(LDL-C)(校正OR=1.585,95%CI1.145~2.193,P=0.005)是eGFR损害的独立危险因素,中介效应分析发现LDL-C介导了SUA导致eGFR损害效应的49.39%。结论部队19~<30岁男性官兵HUA检出率较高,SUA和LDL-C是其eGFR损害的独立危险因素,降低LDL-C可能预防HUA导致的肾损害。Objective To explore the effect of serum uric acid(SUA)on glomerular filtration rate(eGFR)and related factors in male soldiers aged 19-<30 years,and to provide a theoretical basis for ensuring the health of soldiers.Methods The age,body mass index(BMI)and biochemical indexes of male soldiers who underwent physical examination in the this hospital in 2022 were collected and statistically analyzed.Results Compared with other age groups,the highest detection rates of SUA concentration and hyperuricemia were found in officers and soldiers aged 19-<30(P≤0.001);SUA and eGFR were negatively correlated in this age group(r=-0.24,P<0.001);ROC analysis showed that SUA concentration had a predictive value of impaired eGFR(AUC=0.661),and the rate of eGFR impairment increased significantly when SUA was greater than 503μmol/L and the rate of eGFR impairment was significantly increased at SUA greater than 503μmol/L.Regression analysis showed that SUA(corrected OR=1.003,95%CI 1.001-1.006,P=0.018)and low-density lipoprotein cholesterol(LDL-C)(corrected OR=1.585,95%CI 1.145-2.193,P=0.005)were independent risk factors for eGFR impairment.Mediation effect analysis found that LDL-C mediated 49.39%of the effect of SUA leading to eGFR impairment.Conclusion The detection rate of HUA is high in male soldiers aged 19-<30 years in the army.SUA and LDL-C are independent risk factors for eGFR damage.Reducing LDL-C may prevent renal damage caused by HUA.

关 键 词：青年官兵 血尿酸 估算肾小球滤过率 低密度脂蛋白胆固醇 

分 类 号：R692[医药卫生—泌尿科学]