泛免疫炎症指数与原发性膜性肾病患者合并高凝状态关系研究  

Study on the relationship between Pan-immune inflammatory index and hypercoagulable state in patients with idiopathic membranous nephropathy

作　　者：袁铭 王伟鑫 戴春 YUAN Ming;WANG Weixin;DAI Chun(North Anhui Health Vocational College,Suzhou,Anhui 234000,China;Department of Thoracic Surgery,Affiliated Hospital of Nantong University,Nantong,Jiangsu 226000,China;Department of Nephrology,Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002,China)

机构地区：[1]皖北卫生职业学院,安徽宿州234000 [2]南通大学附属医院胸外科,江苏南通226000 [3]徐州医科大学附属医院肾内科,江苏徐州221002

出　　处：《现代医药卫生》2024年第14期2371-2375,共5页Journal of Modern Medicine & Health

基　　金：江苏省卫生健康委员会科研项目(M2020063)。

摘　　要：目的探讨原发性膜性肾病(IMN)患者泛免疫炎症值(PIV)与高凝状态的关系。方法回顾性分析2020年2月至2021年2月在徐州医科大学附属医院肾内科行肾脏穿刺活检术诊断为特发性膜性肾病的280例患者临床资料,根据高凝状态的标准将患者分为高凝组(89例)和对照组(191例),比较2组患者的基线临床资料。结果二元logistic回归分析显示,PIV水平[比值比(OR)=1.002,95%可信区间(95%CI)1.000~1.004,P=0.016]、总胆固醇(OR=1.398,95%CI 1.190~1.642,P<0.001)、抗凝血酶Ⅲ活性(OR=0.903,95%CI 0.871~0.936,P<0.001)是IMN患者发生高凝状态的独立危险因素。结论PIV是IMN患者高凝状态的独立危险因素。在PIV水平较高的IMN患者中,早期可以通过检测PIV水平评估IMN患者的凝血状况,提前采取抗凝等预防方法。Objective To investigate the relationship between Pan-immune inflammation Value(PIV)and hypercoagulable state in patients with idiopathic membranous nephropathy(IMN).Methods Clinical data of 280 patients diagnosed with IMN idiopathic membranous nephropathy who underwent renal biopsy at the Department of Nephrology,Affiliated Hospital of Xuzhou Medical University from February 2020 to February 2021 were retrospectively analyzed.Patients were categorized into the hypercoagulable group(89 cases)and the control group(191 cases)based on criteria for hypercoagulability,and baseline clinical data between the two groups were compared.Results Binary logistic regression analysis revealed that PIV level(OR=1.002,95%CI 1.000-1.004,P=0.016),total cholesterol(OR=1.398,95%CI 1.190-1.642,P<0.001),and antithrombinⅢactivity(OR=0.903,95%CI 0.871-0.936,P<0.001)were independent risk factors for hypercoagulable state in IMN patients.Conclusion PIV is an independent risk factor for hypercoagulable state in patients with IMN.Early assessment of PIV levels in IMN patients with higher PIV levels can aid in evaluating their coagulation status and initiating preventive measures such as anticoagulation therapy.

关 键 词：原发性膜性肾病 泛免疫炎症指数 高凝状态 静脉血栓 相关性 

分 类 号：R692[医药卫生—泌尿科学]