武汉地区表观健康成人血清sTfR和sTfR/lgSF参考区间的建立  

Establishment of reference intervals for serum sTfR and sTfR/lgSF in apparently healthy adults in Wuhan

作　　者：陶翠华 董杉杉[3] 凃茹 李然[2] 李玲[3] 曹树正[3] TAO Cuihua;DONG Shanshan;TU Ru;LI Ran;LI Ling;CAO Shuzheng(Department of Transfusion Medicine,Wuhan Aisa General Hospital,Wuhan 430022,China;Department of Transfusion Medicine,Wuhan Asia Heart Hospital;Department of Clinical Laboratory,Wuhan Asia Heart Hospital)

机构地区：[1]武汉亚心总医院输血科,湖北武汉430022 [2]武汉亚洲心脏病医院输血科 [3]武汉亚洲心脏病医院检验科

出　　处：《中国输血杂志》2024年第7期807-811,共5页Chinese Journal of Blood Transfusion

基　　金：武汉市卫健委科研项目资助(WX23A74);武汉亚心总医院资金项目(2022KYCX1-B08)。

摘　　要：目的 建立武汉地区表观健康成人血清可溶性转铁蛋白受体(soluble transferrin receptor,sTfR)和可溶性转铁蛋白受体与血清铁蛋白常用对数的比值(sTfR/log serum ferritin index,sTfR/lgSF)参考区间,为临床对铁缺乏和缺铁性贫血诊治提供依据。方法 选取武汉亚心总医院表观健康体检者和献血屋献血者273名,检测sTfR、其他铁代谢指标以及超敏C-反应蛋白(high sensitivity C-reactive protein,hsCRP),并计算sTfR/lgSF值,采用百分位数法(P2.5~P97.5)建立sTfR和sTfR/lgSF参考区间。采用Spearman相关分析评价sTfR、sTfR/lgSF与其他铁代谢指标、hsCPR相关性。结果 sTfR水平(M,mg/L)男女(1.01 vs 1.07)间差异不具统计学意义(P>0.05),但男性sTfR/lgSF水平明显低于女性(0.45 vs 0.62),差异有统计学意义(P<0.05);各年龄组间sTfR(M,mg/L)、sTfR/lgSF(M)比较,分别为(1.07 vs 1.02 vs 1.00)、(0.52 vs 0.53 vs 0.51),差异均不具统计学意义(P>0.05);sTfR参考区间为(0.72~1.68)mg/L,根据性别建立sTfR/lgSF参考区间为男性(0.31~0.88)、女性(0.37~1.19);相关性分析结果显示:sTfR、sTfR/lgSF与hsCRP无相关性(r=0.043,P>0.05)、(r=-0.064,P>0.05),而血清铁蛋白(serum ferritin,SF)、血清铁(serum iron,SI)、转铁蛋白饱和度(transferrin saturation,TSAT)与hsCRP均有相关性(r=0.128,P<0.05)、(r=-0.195,P<0.01)、(r=-0.173,P<0.01);sTfR与SF无相关性(r=-0.115,P>0.05),而sTfR/lgSF与SF有显著性相关(r=-0.685,P<0.01)。结论 初步建立了武汉地区表观健康成人血清sTfR及sTfR/lgSF的参考区间。sTfR和sTfR/lgSF不受炎性因子影响,对在炎症作用下血清铁蛋白升高的贫血患者,鉴别是否存在铁缺乏方面有着重大意义。Objective To establish reference intervals for serum soluble transferrin receptor(sTfR) and sTfR/log serum ferritin index(sTfR/lgSF) in apparently healthy adults in the Wuhan area,so as to provide reference for clinical diagnosis and treatment of iron deficiency and iron-deficiency anemia.Methods A total of 273 individuals from the Wuhan Aisa General Hospital,including health examination participants and blood donors,were selected to measure sTfR,other iron metabolism indicators and high sensitivity C-reactive protein(hsCRP).The sTfR/lgSF values were calculated and reference intervals for sTfR and sTfR/lgSF were established using the percentile method(P2.5 to P97.5).Spearman correlation analysis was used to evaluate the relationships between sTfR,sTfR/lgSF,and other iron metabolism indicators,as well as hsCRP.Results The sTfR levels(M,mg/L) between males and females(1.01 vs 1.07) were not statistically significant(P>0.05),but the sTfR/lgSF levels if males were significantly lower than those in females(0.45 vs 0.62)(P<0.05).There was no significant difference in sTfR(M,mg/L) and sTfR/lgSF(M) among different age groups,with values of 1.07 vs 1.02 vs 1.00 and 0.52 vs 0.53 vs 0.51,respectively(P>0.05).The reference interval for STfR was(0.72-1.68) mg/L,the sTfR/lgSF reference interval was(0.31-0.88) for males,and(0.37-1.19) for females.Correlation analysis showed no correlation between sTfR,sTfR/lgSF and hsCRP(r=0.043,P>0.05;r=-0.064,P>0.05),while serum ferritin(SF),serum iron(SI),transferrin saturation(TSAT)were correlated with hsCRP(r=0.128,P<0.05;r=-0.195,P<0.01;r=-0.173,P<0.01).There was no correlation between sTfR and SF(r=-0.115,P>0.05),while sTfR/lgSF was significantly correlated with and SF(r=-0.685,P<0.01).Conclusion Preliminary reference intervals for serum sTfR and sTfR/lgSF in apparently healthy adults in the Wuhan has been established.sTfR and sTfR/lgSF are not affected by inflammatory factors and are significant for identifying iron deficiency in anemia patients with elevated serum ferritin caused by in

关 键 词：可溶性转铁蛋白受体 可溶性转铁蛋白受体/lg铁蛋白 铁缺乏 参考区间 武汉 

分 类 号：R457.1[医药卫生—治疗学] R556.3[医药卫生—临床医学]