56~60周岁固定献血浆者安全性调查分析  

Investigation on the safety of regular plasma donors aged 56-60 years

作　　者：高阳 董科成 马名立 董琰 房东红 苏雨蒙 周蓉 董德梅 GAO Yang;DONG Kecheng;MA Mingli;DONG Yan;FANG Donghong;SU Yumeng;ZHOU Rong;DONG Demei(Beijing Tiantan Biological Products Co.,Ltd,Beijing 100000,China;Shifang Rongsheng Apheresis Plasma Co.,Ltd;Sinopharm Lanzhou Biopharmaceuticals Co.,Ltd;Sinopharm Shanghai Blood Products Co., Ltd.)

机构地区：[1]北京天坛生物制品股份有限公司,北京100000 [2]什邡蓉生单采血浆有限公司 [3]国药集团兰州生物制药有限公司 [4]国药集团上海血液制品有限公司

出　　处：《中国输血杂志》2024年第7期812-815,共4页Chinese Journal of Blood Transfusion

摘　　要：目的 探讨55~60岁固定献血浆者安全性,为我国单采血浆行业保留与招募55~60岁献浆者提供参考。方法 2018—2020年共9家血液制品生产企业55~60岁固定献浆者及当地同龄普通人群为作为研究对象,统计固定献浆者与当地普通人群总蛋白水平、白球比[血浆白蛋白(ALB)/球蛋白(GLB),A/G]、献浆不良反应并进行回顾性分析。结果 56~60周岁固定献血浆人群和普通人群的总蛋白质水平分别为(61.21±5.62)g/L、(60.04±6.93)g/L;白球比分别为1.610±0.299、1.635±0.330,固定献血浆人群和普通人群的总蛋白质水平、A/G差异均具有统计学意义,固定献浆人群总蛋白水平高于普通人群,但A/G略低于普通人群。2018—2020年期间,108家浆站共采浆23 056 302人次,发生不良反应20 932人次,总发生率为0.09%,无严重不良反应发生。结论 55~60岁固定献血浆者献浆安全可靠,保留该年龄段献浆者可缓解血浆原料的供应压力。Objective To investigate the safety of regular plasma donors aged 55 to 60,so as to provide reference for retention and recruitment of elderly plasma donors in China.Methods Plasma donors from 9 blood products manufacturing enterprises from 2018 to 2020 and the local general population were selected as the research objects.The total protein level,albumin and globulin ratio(ALB/GLB,A/G) and adverse reactions of plasma donation of regular plasma donors and local general population were retrospectively analyzed.Results The total protein level(g/L) and A/G of plasma donors aged 56 to 60 and the general population were 61.21±5.62 vs 60.04±6.93 and 1.610±0.299 vs 1.635±0.330,respectively,and the differences were statistically significant.The total protein level of regular plasma donors was higher than that of general population,but A/G was slightly lower than that of general population.From 2018 to 2020,there were a total of 23 056 302 plasma donations in 108 plasma stations,and adverse reactions occurred in 20 932 donations,with a total incidence of 0.09%,with no serious adverse reactions.Conclusion It is safe for regular plasma donors aged 55 to 60 to donate plasma,and the retention of them can alleviate the pressure of plasma supply.

关 键 词：血浆原料 55~60岁献浆者 献浆不良反应 年龄 

分 类 号：R457.14[医药卫生—治疗学] R193.3[医药卫生—临床医学]