胰岛素注射在糖尿病患儿中的效果及对血糖水平的影响研究  

Effect of Insulin Injection in Children with Diabetes and the Influence on Blood Glucose Level

作　　者：张淑红 夏兴芬 肖雨峰 ZHANG Shuhong;XIA Xingfen;XIAO Yufeng(Department of Child Health,Weicheng District People's Hospital,Weifang 261000,Shandong,China;Department of General Surgery,Anqiu Municipal Hospital,Anqiu 262100,Shandong,China;Department of General surgery,Changle County People's Hospital,Weifang 262400,Shandong,China)

机构地区：[1]潍城区人民医院儿保科,山东潍坊261000 [2]安丘市市立医院普外科,山东安丘262100 [3]昌乐县人民医院普外科,山东潍坊262400

出　　处：《糖尿病新世界》2024年第9期8-11,共4页Diabetes New World Magazine

摘　　要：目的探讨胰岛素注射在糖尿病患儿中的治疗效果及对血糖水平的影响。方法选取2021年8月—2023年5月潍城区人民医院收治的96例糖尿病患儿为研究对象,按照信封法分为两组,各48例。对照组采用短效胰岛素治疗,观察组在对照组治疗的基础上联合地特胰岛素注射液治疗,两组均进行3个月干预。比较两组血糖水平、血清Th1及Th2细胞因子水平及不良事件发生率。结果干预3个月后,两组血糖水平均降低,且观察组空腹血糖、餐后2 h血糖及糖化血红蛋白水平低于对照组,差异有统计学意义(P均<0.05)。干预3个月后,两组血清Th1及Th2细胞因子水平得到改善,且观察组白细胞介素-2、白细胞介素-4、白细胞介素-12及肿瘤坏死因子-α水平低于对照组,差异有统计学意义(P均<0.05)。观察组不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论地特胰岛素注射干预用于糖尿病患儿中,可降低其血糖水平,调节血清Th1及Th2细胞因子水平,有助于降低不良事件发生率。Objective To investigate the effect of insulin injection in the treatment of diabetes and the effects on blood glucose levels.Methods A total of 96 diabetic children admitted to Weicheng District People's Hospital from August 2021 to May 2023 were selected as the study objects and divided into two groups according to envelope method,with 48 cases in each group.The control group was treated with short-acting insulin,and the observation group was treated with insulin detemir injection on the basis of the treatment of the control group.Both groups completed 3 months of intervention.The blood glucose levels,serum Th1 and Th2 cytokines levels and the incidence of adverse events of two groups were compared.Results After 3 months of intervention,the blood glucose levels of the two groups were decreased,the levels of fasting plasma glucose,2-hour postprandial plasma glucose and glycated hemoglobin A1c in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).After 3 months of intervention,the levels of serum Th1 and Th2 cytokines in the two groups were improved,the levels of interleukin-2,interleukin-4,interleukin-12 and tumor necrosis factor-αin the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Insulin detemide injection intervention in diabetic children can reduce blood glucose levels,regulate serum Th1 and Th2 cytokine levels, and help reduce the incidence of adverse events.

关 键 词：地特胰岛素注射液 糖尿病患儿 短效胰岛素 血清Th1、Th2细胞因子 

分 类 号：R587[医药卫生—内分泌]